DegronMD - P04843(RPN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S210N	TCGA-49-AAR0	LUAD	TCGA	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.2222
p.R263C	TCGA-66-2768	LUSC	TCGA	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.1111
p.L225M	TCGA-AZ-6598	COAD	TCGA	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.1667
p.T213N	TCGA-EO-A3AY	UCEC	TCGA	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.3056
p.I211M	DO52611	BOCA	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.25
p.Y215C	DO225035	BRCA	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation altering degron motif	0.7087
p.Y215C	DO227817	BRCA	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation altering degron motif	0.7087
p.E204V	DO10582	COAD	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.0556
p.V281I	DO51346	PRAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation blocking ubiquitination signal	0.6389
p.V281I	DO41235	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation blocking ubiquitination signal	0.6389
p.P214L	DO51296	SKCM	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation altering degron motif	0.7582
p.Y226H	DO48032	STAD	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.1389
p.A272V	DO38336	STAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation altering degron motif	0.6936
p.A272V	DO41379	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation altering degron motif	0.6936
p.D212H	DO43162	UCEC	ICGC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.2778
p.F278L	DO42568	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2778
p.F279S	DO42745	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.25
p.S222N	SIDM00216	Colorectal Carcinoma	GDSC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation blocking phosphorylation signal	0.6944
p.S222N	ACH-000989	Colon/Colorectal Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation blocking phosphorylation signal	0.6944
p.S222N	SNU-175	large intestine	COSMIC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation blocking phosphorylation signal	0.6944
p.P223T	SIDM00587	Biliary Tract Carcinoma	GDSC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.2222
p.P223T	ACH-000976	Bile Duct Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.2222
p.P223T	HuCCT1	biliary tract	COSMIC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.2222
p.R204G	SIDM00534	Colorectal Carcinoma	GDSC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.0556
p.R204G	ACH-000986	Colon/Colorectal Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.0556
p.R204G	HT-115	large intestine	COSMIC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.0556
p.R263H	ACH-000960	Leukemia	CCLE	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.1111
p.P223L	ACH-001863	Bile Duct Cancer	CCLE	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.2222
p.L229M	C-33-A	cervix	COSMIC	FKVHYE	LIG_APCC_ABBA_1	214:219	Mutation rewiring degron network	0.0556
p.R278C	OCUM-1	stomach	COSMIC	DSGISS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2778

Kaplan plot for RPN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPN1

UniProt ID: P04843

Entrez ID: 6184

Protein name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPN1 in