DegronMD

Uniprot ID: P04843

Source protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Source gene: RPN1

Class: DEG_SCF_TRCP1_1

Location: 271:276

E3 ligase: BTRC

DEGRON score: 0.5317

ASA_SCORE: 58.1833

COIL: 0.7923

CONS_SCORE: 0.3437

DSS_SCORE: 0.3191

HELIX: 0.0542

FCONS_SCORE: 0.6244

RIG_SCORE: 0.7117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R263C	TCGA-66-2768	LUSC	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1111
p.V281I	DO51346	PRAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.6389
p.V281I	DO41235	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.6389
p.A272V	DO38336	STAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.6936
p.A272V	DO41379	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.6936
p.F278L	DO42568	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.2778
p.F279S	DO42745	UCEC	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.25
p.R263H	ACH-000960	Leukemia	CCLE	DSGISS	DEG_SCF_TRCP1_1	0.1111
p.R278C	OCUM-1	stomach	COSMIC	DSGISS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	DEG_SCF_TRCP1_1	271:276	DSGISS	BTRC	0.5317	More...
Q9BXP8	Pappalysin-2	DEG_SCF_TRCP1_1	212:217	DSGISS	BTRC	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons