DegronMD

Uniprot ID: Q9BXP8

Source protein: Pappalysin-2

Source gene: PAPPA2

Class: DEG_SCF_TRCP1_1

Location: 212:217

E3 ligase: BTRC

DEGRON score: 0.6909

ASA_SCORE: 53.9833

COIL: 0.7608

CONS_SCORE: 0.2513

DSS_SCORE: 0.6742

HELIX: 0.162

FCONS_SCORE: 0.7427

RIG_SCORE: 0.5568

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G214C	TCGA-05-4382	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.76
p.G214C	DO24900	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.76
p.G214A	TCGA-05-4382	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.754
p.G214A	DO24900	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.754
p.R205P	TCGA-35-3615	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1389
p.R205P	TCGA-CN-A63U	HNSC	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1389
p.R205P	DO44454	HNSC	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.1389
p.R205P	DO23627	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.1389
p.Q210H	TCGA-55-8089	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.2778
p.Q210H	DO23690	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.2778
p.K224N	TCGA-73-A9RS	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.25
p.K224N	DO51193	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.25
p.W222C	TCGA-CN-5360	HNSC	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1944
p.W222C	TCGA-OR-A5KB	ACC	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1944
p.W222C	DO14662	HNSC	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.1944
p.S226F	TCGA-ER-A19H	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.0833
p.S226F	DO47299	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.0833
p.G211R	TCGA-GN-A266	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.3056
p.G211R	DO37432	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.3056
p.G211R	ACH-001414	Bladder Cancer	CCLE	DSGISS	DEG_SCF_TRCP1_1	0.3056
p.R204K	TCGA-GN-A4U4	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1111
p.R204K	DO51256	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.1111
p.P223H	TCGA-MP-A4T7	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.1667
p.P223H	DO45370	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.1667
p.K224T	TCGA-RP-A693	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.25
p.K224T	DO51268	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.25
p.P221H	TCGA-VQ-A8P2	STAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	0.2222
p.P221H	DO51761	STAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.2222
p.R205W	DO35114	PACA	ICGC	DSGISS	DEG_SCF_TRCP1_1	0.1389
p.G209E	SIDM01307	Colorectal Carcinoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	0.25
p.A206V	SIDM00834	Colorectal Carcinoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	0.1667
p.A206V	SW1463	large_intestine	COSMIC	DSGISS	DEG_SCF_TRCP1_1	0.1667
p.W202L	SIDM01099	Neuroblastoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	0.0556
p.W202L	ACH-000341	Neuroblastoma	CCLE	DSGISS	DEG_SCF_TRCP1_1	0.0556
p.W202L	SK-N-FI	autonomic_ganglia	COSMIC	DSGISS	DEG_SCF_TRCP1_1	0.0556
p.A206E	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	0.1667
p.A206E	NCI-H647	lung	COSMIC	DSGISS	DEG_SCF_TRCP1_1	0.1667
p.S213T	ACH-001147	Lymphoma	CCLE	DSGISS	DEG_SCF_TRCP1_1	0.7116
p.K203N	ACH-001608	Brain Cancer	CCLE	DSGISS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	DEG_SCF_TRCP1_1	271:276	DSGISS	BTRC	0.5317	More...
Q9BXP8	Pappalysin-2	DEG_SCF_TRCP1_1	212:217	DSGISS	BTRC	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGISS

Degron related mutations and impact score

Drug responses associated with PAPPA2 mutations

All proteins holding degron of DSGISS