DegronMD - Q9BXP8(PAPPA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G214C	TCGA-05-4382	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation altering degron motif	0.76
p.G214C	DO24900	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation altering degron motif	0.76
p.G214A	TCGA-05-4382	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation altering degron motif	0.754
p.G214A	DO24900	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation altering degron motif	0.754
p.R205P	TCGA-35-3615	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1389
p.R205P	TCGA-CN-A63U	HNSC	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1389
p.R205P	DO44454	HNSC	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1389
p.R205P	DO23627	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1389
p.T789P	TCGA-52-7811	LUSC	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.1111
p.T789P	DO26569	LUSC	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.1111
p.Q210H	TCGA-55-8089	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.2778
p.Q210H	DO23690	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.2778
p.K224N	TCGA-73-A9RS	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation substituting flanking lysine	0.25
p.K224N	DO51193	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation substituting flanking lysine	0.25
p.R784Q	TCGA-BH-A18U	BRCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.25
p.R784Q	TCGA-FB-AAPU	PAAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.25
p.R784Q	DO5200	BRCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.25
p.R784Q	DO218966	PAAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.25
p.A775T	TCGA-C8-A26V	BRCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.3056
p.A775T	DO4287	BRCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.3056
p.W222C	TCGA-CN-5360	HNSC	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1944
p.W222C	TCGA-OR-A5KB	ACC	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1944
p.W222C	DO14662	HNSC	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1944
p.T767M	TCGA-D3-A51G	SKCM	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.T767M	DO227979	COCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.T767M	DO47700	SKCM	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.T767M	SIDM01307	Colorectal Carcinoma	GDSC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.S226F	TCGA-ER-A19H	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.0833
p.S226F	DO47299	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.0833
p.G211R	TCGA-GN-A266	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.3056
p.G211R	DO37432	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.3056
p.G211R	ACH-001414	Bladder Cancer	CCLE	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.3056
p.R204K	TCGA-GN-A4U4	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1111
p.R204K	DO51256	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1111
p.S780T	TCGA-MN-A4N5	LUAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation altering degron motif	0.6005
p.S780T	DO45332	LUAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation altering degron motif	0.6005
p.P788R	TCGA-MP-A4SV	LUAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.1389
p.P788R	DO45339	LUAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.1389
p.P223H	TCGA-MP-A4T7	LUAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1667
p.P223H	DO45370	LUAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1667
p.E766D	TCGA-R6-A6DQ	ESCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0556
p.K224T	TCGA-RP-A693	SKCM	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation substituting flanking lysine	0.25
p.K224T	DO51268	SKCM	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation substituting flanking lysine	0.25
p.P221H	TCGA-VQ-A8P2	STAD	TCGA	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.2222
p.P221H	DO51761	STAD	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.2222
p.T767P	DO225328	BRCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.C771S	DO222565	COCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.1944
p.P778L	DO220880	MELA	ICGC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation altering degron motif	0.7582
p.R205W	DO35114	PACA	ICGC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1389
p.G209E	SIDM01307	Colorectal Carcinoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.25
p.S790I	SIDM01203	Other Solid Cancers	GDSC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.S790I	ACH-002291	Embryonal Cancer	CCLE	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.S790I	NTERA-2_cl_D1	testis	COSMIC	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.0833
p.A206V	SIDM00834	Colorectal Carcinoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1667
p.A206V	SW1463	large intestine	COSMIC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1667
p.W202L	SIDM01099	Neuroblastoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.0556
p.W202L	ACH-000341	Neuroblastoma	CCLE	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.0556
p.W202L	SK-N-FI	autonomic ganglia	COSMIC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.0556
p.A206E	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1667
p.A206E	NCI-H647	lung	COSMIC	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation rewiring degron network	0.1667
p.P786Q	ACH-000393	Liver Cancer	CCLE	PTPKSE	DEG_SCF_FBW7_2	776:781	Mutation rewiring degron network	0.1944
p.S213T	ACH-001147	Lymphoma	CCLE	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation altering degron motif	0.7116
p.K203N	ACH-001608	Brain Cancer	CCLE	DSGISS	DEG_SCF_TRCP1_1	212:217	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAPPA2

UniProt ID: Q9BXP8

Entrez ID: 60676

Protein name: Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAPPA2 in