DegronMD

Uniprot ID: Q9BXP8

Source protein: Pappalysin-2

Source gene: PAPPA2

Class: DEG_SCF_FBW7_2

Location: 776:781

E3 ligase: FBXW7

DEGRON score: 0.8972

ASA_SCORE: 79.3667

COIL: 0.8445

CONS_SCORE: 0.7627

DSS_SCORE: 0.4962

HELIX: 0.1128

FCONS_SCORE: 1.0366

RIG_SCORE: 0.6913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T789P	TCGA-52-7811	LUSC	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.1111
p.T789P	DO26569	LUSC	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.1111
p.R784Q	TCGA-BH-A18U	BRCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.25
p.R784Q	TCGA-FB-AAPU	PAAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.25
p.R784Q	DO5200	BRCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.25
p.R784Q	DO218966	PAAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.25
p.A775T	TCGA-C8-A26V	BRCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.3056
p.A775T	DO4287	BRCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.3056
p.T767M	TCGA-D3-A51G	SKCM	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.T767M	DO227979	COCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.T767M	DO47700	SKCM	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.T767M	SIDM01307	Colorectal Carcinoma	GDSC	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.S780T	TCGA-MN-A4N5	LUAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.6005
p.S780T	DO45332	LUAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.6005
p.P788R	TCGA-MP-A4SV	LUAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.1389
p.P788R	DO45339	LUAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.1389
p.E766D	TCGA-R6-A6DQ	ESCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.0556
p.T767P	DO225328	BRCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.C771S	DO222565	COCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.1944
p.P778L	DO220880	MELA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.7582
p.S790I	SIDM01203	Other Solid Cancers	GDSC	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.S790I	ACH-002291	Embryonal Cancer	CCLE	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.S790I	NTERA-2_cl_D1	testis	COSMIC	PTPKSE	DEG_SCF_FBW7_2	0.0833
p.P786Q	ACH-000393	Liver Cancer	CCLE	PTPKSE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons