DegronMD

Uniprot ID: Q8WXF7

Source protein: Atlastin-1

Source gene: ATL1

Class: DEG_SCF_FBW7_2

Location: 543:548

E3 ligase: FBXW7

DEGRON score: 0.5876

ASA_SCORE: 107.05

COIL: 0.9132

CONS_SCORE: 0.2286

DSS_SCORE: 0.6084

HELIX: 0.0622

FCONS_SCORE: 0.76

RIG_SCORE: 0.6289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H536Q	TCGA-2W-A8YY	CESC	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.1389
p.H536Q	DO223732	CESC	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.1389
p.K555N	TCGA-AP-A056	UCEC	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.25
p.K555N	TCGA-AZ-4315	COAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.25
p.K555N	TCGA-BR-8680	STAD	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.25
p.P543T	TCGA-D3-A3CE	SKCM	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.7031
p.E548G	TCGA-EE-A2MI	SKCM	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.7199
p.Q540E	TCGA-ZF-AA56	BLCA	TCGA	PTPKSE	DEG_SCF_FBW7_2	0.25
p.Q540E	DO219099	BLCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.25
p.K550N	DO8842	COAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.2778
p.K550N	DO47769	STAD	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.2778
p.K550N	DO43971	UCEC	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.2778
p.S542L	DO227549	COCA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.3056
p.E543K	DO222843	MELA	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.7022
p.E543G	DO37531	SKCM	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.7199
p.P538T	DO37405	SKCM	ICGC	PTPKSE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons