DegronMD

Uniprot ID: Q96RP9

Source protein: Elongation factor G, mitochondrial

Source gene: GFM1

Class: LIG_APCC_ABBA_1

Location: 480:485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9527

ASA_SCORE: 55.8833

COIL: 0.2123

CONS_SCORE: 0.6207

DSS_SCORE: 0.3425

HELIX: 0.0143

FCONS_SCORE: 0.8617

RIG_SCORE: 0.8673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E476Q	TCGA-BT-A20J	BLCA	TCGA	FKVYFD	LIG_APCC_ABBA_1	0.2222
p.E476Q	DO457	BLCA	ICGC	FKVYFD	LIG_APCC_ABBA_1	0.2222
p.I493L	DO231992	LICA	ICGC	FKVYFD	LIG_APCC_ABBA_1	0.1111
p.M474L	SIDM00450	Acute Myeloid Leukemia	GDSC	FKVYFD	LIG_APCC_ABBA_1	0.1667
p.M474L	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	FKVYFD	LIG_APCC_ABBA_1	0.1667
p.L482M	SIDM00087	Plasma Cell Myeloma	GDSC	FKVYFD	LIG_APCC_ABBA_1	0.711
p.L482M	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	FKVYFD	LIG_APCC_ABBA_1	0.711
p.N478H	SIDM00346	Chronic Myelogenous Leukemia	GDSC	FKVYFD	LIG_APCC_ABBA_1	0.2778
p.N478H	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	FKVYFD	LIG_APCC_ABBA_1	0.2778
p.D481Y	SIDM01105	Melanoma	GDSC	FKVYFD	LIG_APCC_ABBA_1	0.7325
p.D481Y	SK-MEL-3	skin	COSMIC	FKVYFD	LIG_APCC_ABBA_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RP9	Elongation factor G, mitochondrial	LIG_APCC_ABBA_1	480:485	FKVYFD	APC,CDC20,FZR1	0.9527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons