DegronMD - Q96RP9(GFM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A454S	TCGA-06-5416	GBM	TCGA	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.1944
p.A454S	DO10880	GBM	ICGC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.1944
p.S452L	TCGA-AA-3679	COAD	TCGA	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.25
p.S452L	DO8890	COAD	ICGC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.25
p.E476Q	TCGA-BT-A20J	BLCA	TCGA	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2222
p.E476Q	DO457	BLCA	ICGC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2222
p.I493L	DO231992	LICA	ICGC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1111
p.D433Y	DO228976	LICA	ICGC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.1389
p.V446F	DO229018	LICA	ICGC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation altering degron motif	0.7068
p.E430V	SIDM02050	Colorectal Carcinoma	GDSC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.0556
p.M474L	SIDM00450	Acute Myeloid Leukemia	GDSC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1667
p.M474L	PL-21	haematopoietic and lymphoid tissue	COSMIC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1667
p.G441C	SIDM00336	Melanoma	GDSC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation altering degron motif	0.76
p.G441C	MEL-JUSO	skin	COSMIC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation altering degron motif	0.76
p.L482M	SIDM00087	Plasma Cell Myeloma	GDSC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.711
p.L482M	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.711
p.N478H	SIDM00346	Chronic Myelogenous Leukemia	GDSC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.N478H	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.D481Y	SIDM01105	Melanoma	GDSC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.7325
p.D481Y	SK-MEL-3	skin	COSMIC	FKVYFD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.7325
p.M455L	ACH-000218	Leukemia	CCLE	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.1667
p.M455L	PL-21	haematopoietic and lymphoid tissue	COSMIC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.1667
p.N459H	ACH-000301	Leukemia	CCLE	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.0556
p.N459H	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	SMESIHVPDP	DEG_COP1_1	440:449	Mutation rewiring degron network	0.0556

Kaplan plot for GFM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GFM1

UniProt ID: Q96RP9

Entrez ID: 85476

Protein name: Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GFM1 in