DegronMD

Uniprot ID: Q96RP9

Source protein: Elongation factor G, mitochondrial

Source gene: GFM1

Class: DEG_COP1_1

Location: 440:449

E3 ligase: COP1

DEGRON score: 0.9401

ASA_SCORE: 62.5

COIL: 0.7888

CONS_SCORE: 0.6689

DSS_SCORE: 0.3572

HELIX: 0.0078

FCONS_SCORE: 1.1928

RIG_SCORE: 0.7513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A454S	TCGA-06-5416	GBM	TCGA	SMESIHVPDP	DEG_COP1_1	0.1944
p.A454S	DO10880	GBM	ICGC	SMESIHVPDP	DEG_COP1_1	0.1944
p.S452L	TCGA-AA-3679	COAD	TCGA	SMESIHVPDP	DEG_COP1_1	0.25
p.S452L	DO8890	COAD	ICGC	SMESIHVPDP	DEG_COP1_1	0.25
p.D433Y	DO228976	LICA	ICGC	SMESIHVPDP	DEG_COP1_1	0.1389
p.V446F	DO229018	LICA	ICGC	SMESIHVPDP	DEG_COP1_1	0.7068
p.E430V	SIDM02050	Colorectal Carcinoma	GDSC	SMESIHVPDP	DEG_COP1_1	0.0556
p.G441C	SIDM00336	Melanoma	GDSC	SMESIHVPDP	DEG_COP1_1	0.76
p.G441C	MEL-JUSO	skin	COSMIC	SMESIHVPDP	DEG_COP1_1	0.76
p.M455L	ACH-000218	Leukemia	CCLE	SMESIHVPDP	DEG_COP1_1	0.1667
p.M455L	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	SMESIHVPDP	DEG_COP1_1	0.1667
p.N459H	ACH-000301	Leukemia	CCLE	SMESIHVPDP	DEG_COP1_1	0.0556
p.N459H	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	SMESIHVPDP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RP9	Elongation factor G, mitochondrial	DEG_COP1_1	440:449	SMESIHVPDP	COP1	0.9401	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons