DegronMD

Uniprot ID: O00115

Source protein: Deoxyribonuclease-2-alpha

Source gene: DNASE2

Class: LIG_APCC_ABBA_1

Location: 92:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7557

ASA_SCORE: 36.3

COIL: 0.5472

CONS_SCORE: 0.689

DSS_SCORE: 0.5633

HELIX: 0.1222

FCONS_SCORE: 1.4586

RIG_SCORE: 0.7844

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q89K	DO229006	LICA	ICGC	FLLYND	LIG_APCC_ABBA_1	0.25
p.S88R	TCGA-86-8056	LUAD	TCGA	FLLYND	LIG_APCC_ABBA_1	0.2222
p.S88R	DO24950	LUAD	ICGC	FLLYND	LIG_APCC_ABBA_1	0.2222
p.S88N	TCGA-A6-2686	COAD	TCGA	FLLYND	LIG_APCC_ABBA_1	0.2222
p.S88N	DO7828	COAD	ICGC	FLLYND	LIG_APCC_ABBA_1	0.2222
p.S88I	SIDM00386	Ewing's Sarcoma	GDSC	FLLYND	LIG_APCC_ABBA_1	0.2222
p.S88I	ACH-000391	Bone Cancer	CCLE	FLLYND	LIG_APCC_ABBA_1	0.2222
p.S88I	MHH-ES-1	bone	COSMIC	FLLYND	LIG_APCC_ABBA_1	0.2222
p.N86S	TCGA-DD-A118	LIHC	TCGA	FLLYND	LIG_APCC_ABBA_1	0.1667
p.N86S	DO22905	LIHC	ICGC	FLLYND	LIG_APCC_ABBA_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00115	Deoxyribonuclease-2-alpha	LIG_APCC_ABBA_1	92:97	FLLYND	APC,CDC20,FZR1	0.7557	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons