DegronMD

Uniprot ID: Q9BZM6

Source protein: UL16-binding protein 1

Source gene: ULBP1

Class: LIG_APCC_ABBA_1

Location: 197:202

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7927

ASA_SCORE: 68.6167

COIL: 0.1592

CONS_SCORE: 0.5952

DSS_SCORE: 0.171

HELIX: 0.8372

FCONS_SCORE: 1.1892

RIG_SCORE: 0.9581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S212C	TCGA-21-5782	LUSC	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.0556
p.S212C	DO27120	LUSC	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.0556
p.D206Y	TCGA-73-A9RS	LUAD	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.2222
p.D206Y	DO51193	LUAD	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.2222
p.F197V	TCGA-76-6662	GBM	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.5957
p.F197V	DO11681	GBM	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.5957
p.F197L	TCGA-AJ-A3EL	UCEC	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.587
p.F197L	DO41542	UCEC	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.587
p.K191N	TCGA-AX-A2HH	UCEC	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.2778
p.K191N	DO43057	UCEC	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.2778
p.W193R	TCGA-CR-7370	HNSC	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.2222
p.W193R	DO14426	HNSC	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.2222
p.P211L	TCGA-EE-A29C	SKCM	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.0833
p.P211L	DO222727	MELA	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.0833
p.P211L	DO38028	SKCM	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.0833
p.M204L	TCGA-EE-A3AB	SKCM	TCGA	FLMYWE	LIG_APCC_ABBA_1	0.2778
p.M204L	DO222670	MELA	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.2778
p.M204L	DO38057	SKCM	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.2778
p.D189G	DO222877	COCA	ICGC	FLMYWE	LIG_APCC_ABBA_1	0.1111
p.L187M	SIDM01180	Hepatocellular Carcinoma	GDSC	FLMYWE	LIG_APCC_ABBA_1	0.0556
p.L187M	ACH-000478	Liver Cancer	CCLE	FLMYWE	LIG_APCC_ABBA_1	0.0556
p.L187M	SNU-387	liver	COSMIC	FLMYWE	LIG_APCC_ABBA_1	0.0556
p.M199I	SIDM00929	Chondrosarcoma	GDSC	FLMYWE	LIG_APCC_ABBA_1	0.6507
p.S212Y	ACH-002256	Leukemia	CCLE	FLMYWE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZM6	UL16-binding protein 1	LIG_APCC_ABBA_1	197:202	FLMYWE	APC,CDC20,FZR1	0.7927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons