DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FMPHLE
Uniprot ID:
Q8NDH2
Source protein:
Leucine-rich repeat transmembrane protein CCDC168
Source gene:
CCDC168
Class:
LIG_APCC_ABBA_1
Location:
4722:4727
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9192
ASA_SCORE:
106.7
COIL:
0.8528
CONS_SCORE:
0
DSS_SCORE:
0.5814
HELIX:
0.0932
FCONS_SCORE:
0
RIG_SCORE:
0.7302
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC168 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FMPHLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
LIG_APCC_ABBA_1
4722:4727
FMPHLE
APC,CDC20,FZR1
0.9192
More...