DegronMD

Uniprot ID: O15127

Source protein: Secretory carrier-associated membrane protein 2

Source gene: SCAMP2

Class: LIG_APCC_ABBA_1

Location: 37:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.993

ASA_SCORE: 55.7667

COIL: 0.7012

CONS_SCORE: 0.3975

DSS_SCORE: 0.5649

HELIX: 0.2225

FCONS_SCORE: 1.4927

RIG_SCORE: 0.7274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A29T	TCGA-55-8512	LUAD	TCGA	FNPFSE	LIG_APCC_ABBA_1	0.1111
p.A29T	DO23635	LUAD	ICGC	FNPFSE	LIG_APCC_ABBA_1	0.1111
p.A29D	TCGA-AB-2827	LAML	TCGA	FNPFSE	LIG_APCC_ABBA_1	0.1111
p.A29D	DO22032	LAML	ICGC	FNPFSE	LIG_APCC_ABBA_1	0.1111
p.P39S	TCGA-D3-A8GJ	SKCM	TCGA	FNPFSE	LIG_APCC_ABBA_1	0.6752
p.P39S	DO50285	SKCM	ICGC	FNPFSE	LIG_APCC_ABBA_1	0.6752
p.F40L	DO233726	GACA	ICGC	FNPFSE	LIG_APCC_ABBA_1	0.6981
p.A46E	DO229006	LICA	ICGC	FNPFSE	LIG_APCC_ABBA_1	0.2222
p.A45V	DO51129	PRAD	ICGC	FNPFSE	LIG_APCC_ABBA_1	0.25
p.A46V	SIDM00458	Acute Myeloid Leukemia	GDSC	FNPFSE	LIG_APCC_ABBA_1	0.2222
p.A46V	SIDM00999	Bladder Carcinoma	GDSC	FNPFSE	LIG_APCC_ABBA_1	0.2222
p.A46V	SIDM01413	Oral Cavity Carcinoma	GDSC	FNPFSE	LIG_APCC_ABBA_1	0.2222
p.A46V	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	FNPFSE	LIG_APCC_ABBA_1	0.2222
p.A46V	639-V	urinary_tract	COSMIC	FNPFSE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15127	Secretory carrier-associated membrane protein 2	LIG_APCC_ABBA_1	37:42	FNPFSE	APC,CDC20,FZR1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons