DegronMD - O15127(SCAMP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A29T	TCGA-55-8512	LUAD	TCGA	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.0833
p.A29T	TCGA-55-8512	LUAD	TCGA	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1111
p.A29T	DO23635	LUAD	ICGC	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.0833
p.A29T	DO23635	LUAD	ICGC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1111
p.D11N	TCGA-5P-A9KC	KIRP	TCGA	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.2222
p.D11N	DO223954	KIRP	ICGC	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.2222
p.A29D	TCGA-AB-2827	LAML	TCGA	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.0833
p.A29D	TCGA-AB-2827	LAML	TCGA	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1111
p.A29D	DO22032	LAML	ICGC	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.0833
p.A29D	DO22032	LAML	ICGC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.1111
p.L26M	TCGA-CV-A6K2	HNSC	TCGA	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1667
p.L26M	DO52079	HNSC	ICGC	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1667
p.P39S	TCGA-D3-A8GJ	SKCM	TCGA	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation altering degron motif	0.6752
p.P39S	DO50285	SKCM	ICGC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation altering degron motif	0.6752
p.F40L	DO233726	GACA	ICGC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation altering degron motif	0.6981
p.A46E	DO229006	LICA	ICGC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.P8S	DO222749	MELA	ICGC	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1389
p.A45V	DO51129	PRAD	ICGC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.25
p.P8H	DO37515	SKCM	ICGC	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1389
p.A46V	SIDM00458	Acute Myeloid Leukemia	GDSC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A46V	SIDM00999	Bladder Carcinoma	GDSC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A46V	SIDM01413	Oral Cavity Carcinoma	GDSC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A46V	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.A46V	639-V	urinary tract	COSMIC	FNPFSE	LIG_APCC_ABBA_1	37:42	Mutation rewiring degron network	0.2222
p.V13M	ACH-001843	Bile Duct Cancer	CCLE	VNPFQD	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.2778

Kaplan plot for SCAMP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAMP2

UniProt ID: O15127

Entrez ID: 10066

Protein name: Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAMP2 in