DegronMD

Uniprot ID: O15127

Source protein: Secretory carrier-associated membrane protein 2

Source gene: SCAMP2

Class: LIG_APCC_ABBA_1

Location: 15:20

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9921

ASA_SCORE: 51.4333

COIL: 0.8912

CONS_SCORE: 0.4319

DSS_SCORE: 0.5628

HELIX: 0.076

FCONS_SCORE: 1.1077

RIG_SCORE: 0.7282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A29T	TCGA-55-8512	LUAD	TCGA	VNPFQD	LIG_APCC_ABBA_1	0.0833
p.A29T	DO23635	LUAD	ICGC	VNPFQD	LIG_APCC_ABBA_1	0.0833
p.D11N	TCGA-5P-A9KC	KIRP	TCGA	VNPFQD	LIG_APCC_ABBA_1	0.2222
p.D11N	DO223954	KIRP	ICGC	VNPFQD	LIG_APCC_ABBA_1	0.2222
p.A29D	TCGA-AB-2827	LAML	TCGA	VNPFQD	LIG_APCC_ABBA_1	0.0833
p.A29D	DO22032	LAML	ICGC	VNPFQD	LIG_APCC_ABBA_1	0.0833
p.L26M	TCGA-CV-A6K2	HNSC	TCGA	VNPFQD	LIG_APCC_ABBA_1	0.1667
p.L26M	DO52079	HNSC	ICGC	VNPFQD	LIG_APCC_ABBA_1	0.1667
p.P8S	DO222749	MELA	ICGC	VNPFQD	LIG_APCC_ABBA_1	0.1389
p.P8H	DO37515	SKCM	ICGC	VNPFQD	LIG_APCC_ABBA_1	0.1389
p.V13M	ACH-001843	Bile Duct Cancer	CCLE	VNPFQD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15127	Secretory carrier-associated membrane protein 2	LIG_APCC_ABBA_1	15:20	VNPFQD	APC,CDC20,FZR1	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons