DegronMD

Uniprot ID: Q9H1B5

Source protein: Xylosyltransferase 2

Source gene: XYLT2

Class: LIG_APCC_ABBA_1

Location: 138:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9832

ASA_SCORE: 59.0333

COIL: 0.9082

CONS_SCORE: 0.3292

DSS_SCORE: 0.6338

HELIX: 0.0303

FCONS_SCORE: 1.1998

RIG_SCORE: 0.5869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A150T	TCGA-A5-A0G2	UCEC	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.1389
p.A150T	DO41235	UCEC	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.1389
p.G145V	TCGA-DF-A2KU	UCEC	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.2778
p.G145V	DO223286	UCEC	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.2778
p.G129V	TCGA-EE-A3AG	SKCM	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.0833
p.G129V	DO37471	SKCM	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.0833
p.P139Q	TCGA-ER-A19P	SKCM	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.5924
p.P139Q	DO47623	SKCM	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.5924
p.G149V	TCGA-G2-A3VY	BLCA	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.1667
p.G149V	DO590	BLCA	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.1667
p.E148Q	TCGA-K4-A3WU	BLCA	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.1944
p.E148Q	DO451	BLCA	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.1944
p.A135V	TCGA-L5-A4OI	ESCA	TCGA	FPPHGD	LIG_APCC_ABBA_1	0.25
p.Q152K	DO222475	MELA	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.0833
p.A131V	DO229078	PRAD	ICGC	FPPHGD	LIG_APCC_ABBA_1	0.1389
p.G134W	SIDM01146	Gastric Carcinoma	GDSC	FPPHGD	LIG_APCC_ABBA_1	0.2222
p.G134W	ACH-000932	Gastric Cancer	CCLE	FPPHGD	LIG_APCC_ABBA_1	0.2222
p.V147M	SIDM01051	Ovarian Carcinoma	GDSC	FPPHGD	LIG_APCC_ABBA_1	0.2222
p.V147M	ACH-000936	Ovarian Cancer	CCLE	FPPHGD	LIG_APCC_ABBA_1	0.2222
p.V147M	EFO-27	ovary	COSMIC	FPPHGD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1B5	Xylosyltransferase 2	LIG_APCC_ABBA_1	138:143	FPPHGD	APC,CDC20,FZR1	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons