DegronMD - Q9H1B5(XYLT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A150T	TCGA-A5-A0G2	UCEC	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1389
p.A150T	DO41235	UCEC	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1389
p.G862R	TCGA-BR-6566	STAD	TCGA	RLR	DEG_APCC_TPR_1	863:865	Mutation rewiring degron network	0.3056
p.G862R	DO38217	STAD	ICGC	RLR	DEG_APCC_TPR_1	863:865	Mutation rewiring degron network	0.3056
p.G145V	TCGA-DF-A2KU	UCEC	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.G145V	DO223286	UCEC	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.G129V	TCGA-EE-A3AG	SKCM	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.G129V	DO37471	SKCM	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.P139Q	TCGA-ER-A19P	SKCM	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5924
p.P139Q	DO47623	SKCM	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5924
p.G149V	TCGA-G2-A3VY	BLCA	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.G149V	DO590	BLCA	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.E148Q	TCGA-K4-A3WU	BLCA	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E148Q	DO451	BLCA	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.A135V	TCGA-L5-A4OI	ESCA	TCGA	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.P857S	TCGA-PG-A6IB	UCEC	TCGA	RLR	DEG_APCC_TPR_1	863:865	Mutation rewiring degron network	0.1667
p.P857S	DO52419	UCEC	ICGC	RLR	DEG_APCC_TPR_1	863:865	Mutation rewiring degron network	0.1667
p.Q152K	DO222475	MELA	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.A131V	DO229078	PRAD	ICGC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1389
p.G134W	SIDM01146	Gastric Carcinoma	GDSC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222
p.G134W	ACH-000932	Gastric Cancer	CCLE	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222
p.V147M	SIDM01051	Ovarian Carcinoma	GDSC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222
p.V147M	ACH-000936	Ovarian Cancer	CCLE	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222
p.V147M	EFO-27	ovary	COSMIC	FPPHGD	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222

Kaplan plot for XYLT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XYLT2

UniProt ID: Q9H1B5

Entrez ID: 64132

Protein name: Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XYLT2 in