DegronMD

Uniprot ID: Q9H1B5

Source protein: Xylosyltransferase 2

Source gene: XYLT2

Class: DEG_APCC_TPR_1

Location: 863:865

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7158

ASA_SCORE: 133.1667

COIL: 0.734

CONS_SCORE: 0.3741

DSS_SCORE: 0.9092

HELIX: 0.0117

FCONS_SCORE: 1.0254

RIG_SCORE: 0.7073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G862R	TCGA-BR-6566	STAD	TCGA	RLR	DEG_APCC_TPR_1	0.3056
p.G862R	DO38217	STAD	ICGC	RLR	DEG_APCC_TPR_1	0.3056
p.P857S	TCGA-PG-A6IB	UCEC	TCGA	RLR	DEG_APCC_TPR_1	0.1667
p.P857S	DO52419	UCEC	ICGC	RLR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49918	Cyclin-dependent kinase inhibitor 1C	DEG_APCC_TPR_1	314:316	RLR	APC,CDC20,FZR1	0.9942	More...
Q86Y38	Xylosyltransferase 1	DEG_APCC_TPR_1	957:959	RLR	APC,CDC20,FZR1	0.9261	More...
Q9H1B5	Xylosyltransferase 2	DEG_APCC_TPR_1	863:865	RLR	APC,CDC20,FZR1	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons