DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RLR
Uniprot ID:
P49918
Source protein:
Cyclin-dependent kinase inhibitor 1C
Source gene:
CDKN1C
Class:
DEG_APCC_TPR_1
Location:
314:316
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9942
ASA_SCORE:
149.2
COIL:
0.8447
CONS_SCORE:
0.7674
DSS_SCORE:
0.9692
HELIX:
0.1267
FCONS_SCORE:
1.0921
RIG_SCORE:
0.7308
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R316W
TCGA-EO-A22R
UCEC
TCGA
RLR
DEG_APCC_TPR_1
0.8634
p.R316W
DO42713
UCEC
ICGC
RLR
DEG_APCC_TPR_1
0.8634
Drug responses associated with CDKN1C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49918
Cyclin-dependent kinase inhibitor 1C
DEG_APCC_TPR_1
314:316
RLR
APC,CDC20,FZR1
0.9942
More...
Q86Y38
Xylosyltransferase 1
DEG_APCC_TPR_1
957:959
RLR
APC,CDC20,FZR1
0.9261
More...
Q9H1B5
Xylosyltransferase 2
DEG_APCC_TPR_1
863:865
RLR
APC,CDC20,FZR1
0.7158
More...