CDKN1C
UniProt ID: P49918
Entrez ID: 1028
Protein name: Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life....
FUNCTION: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
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GO - Biological processes (BP):
adrenal gland development [GO:0030325]; aging [GO:0007568]; camera-type eye development [GO:0043010]; cell cycle [GO:0007049]; digestive system development [GO:0055123]; embryonic placenta morphogenesis [GO:0060669]; genomic imprinting [GO:0071514]; kidney development [GO:0001822]; multicellular org...
adrenal gland development [GO:0030325]; aging [GO:0007568]; camera-type eye development [GO:0043010]; cell cycle [GO:0007049]; digestive system development [GO:0055123]; embryonic placenta morphogenesis [GO:0060669]; genomic imprinting [GO:0071514]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; myeloid cell differentiation [GO:0030099]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of exit from mitosis [GO:0007096]; regulation of lens fiber cell differentiation [GO:1902746]; skeletal system development [GO:0001501]; uterus development [GO:0060065]
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GO - Molecular function (MF):
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein-containing complex binding [GO:0044877]; protein kinase inhibitor activity [GO:0004860]...
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein-containing complex binding [GO:0044877]; protein kinase inhibitor activity [GO:0004860]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; nucleus [GO:0005634]
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CDKN1C
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Kaplan plot for CDKN1C in
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*NOTE: the Kaplan plots were collected from OncoLnc