DegronMD

Uniprot ID: P49918

Source protein: Cyclin-dependent kinase inhibitor 1C

Source gene: CDKN1C

Class: DEG_CRL4_CDT2_1

Location: 270:282

E3 ligase: DTL

DEGRON score: 0.9971

ASA_SCORE: 86.5154

COIL: 0.6994

CONS_SCORE: 0.6747

DSS_SCORE: 0.4478

HELIX: 0.1258

FCONS_SCORE: 1.8859

RIG_SCORE: 0.7512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G269R	DO45079	LINC	ICGC	PLISDFFAKRKRS	DEG_CRL4_CDT2_1	0.3056
p.A283V	DO232761	PBCA	ICGC	PLISDFFAKRKRS	DEG_CRL4_CDT2_1	0.3056
p.E285D	DO38404	STAD	ICGC	PLISDFFAKRKRS	DEG_CRL4_CDT2_1	0.25
p.K280N	DO229268	THCA	ICGC	PLISDFFAKRKRS	DEG_CRL4_CDT2_1	0.6918
p.I272V	SIDM00118	Colorectal Carcinoma	GDSC	PLISDFFAKRKRS	DEG_CRL4_CDT2_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49918	Cyclin-dependent kinase inhibitor 1C	DEG_CRL4_CDT2_1	270:282	PLISDFFAKRKRS	DTL	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons