DegronMD

Uniprot ID: Q86Y38

Source protein: Xylosyltransferase 1

Source gene: XYLT1

Class: DEG_APCC_TPR_1

Location: 957:959

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9261

ASA_SCORE: 128.3667

COIL: 0.6633

CONS_SCORE: 0.3736

DSS_SCORE: 0.9121

HELIX: 0.0097

FCONS_SCORE: 1.1388

RIG_SCORE: 0.6994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V952A	TCGA-CN-4727	HNSC	TCGA	RLR	DEG_APCC_TPR_1	0.1944
p.V952A	DO14258	HNSC	ICGC	RLR	DEG_APCC_TPR_1	0.1944
p.A951T	TCGA-DG-A2KJ	CESC	TCGA	RLR	DEG_APCC_TPR_1	0.1667
p.A951T	DO51594	CESC	ICGC	RLR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49918	Cyclin-dependent kinase inhibitor 1C	DEG_APCC_TPR_1	314:316	RLR	APC,CDC20,FZR1	0.9942	More...
Q86Y38	Xylosyltransferase 1	DEG_APCC_TPR_1	957:959	RLR	APC,CDC20,FZR1	0.9261	More...
Q9H1B5	Xylosyltransferase 2	DEG_APCC_TPR_1	863:865	RLR	APC,CDC20,FZR1	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons