DegronMD

Uniprot ID: Q9UGM5

Source protein: Fetuin-B

Source gene: FETUB

Class: LIG_APCC_ABBA_1

Location: 324:329

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 79.6167

COIL: 0.7677

CONS_SCORE: 0.4477

DSS_SCORE: 0.6289

HELIX: 0.0508

FCONS_SCORE: 1.251

RIG_SCORE: 0.7632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q335H	TCGA-17-Z045	LUAD	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1667
p.Q335H	TCGA-EE-A3AA	SKCM	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1667
p.E337K	TCGA-DK-A3IT	BLCA	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1111
p.E337K	TCGA-FR-A8YC	SKCM	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1111
p.E337K	TCGA-UY-A9PB	BLCA	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1111
p.P320T	TCGA-DK-AA77	BLCA	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.2222
p.G336E	TCGA-EE-A29E	SKCM	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1389
p.G336E	TCGA-EE-A2M5	SKCM	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1389
p.G336E	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	FPVHLD	LIG_APCC_ABBA_1	0.1389
p.G336E	KYSE-270	oesophagus	COSMIC	FPVHLD	LIG_APCC_ABBA_1	0.1389
p.G336R	TCGA-EE-A2GR	SKCM	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1389
p.G336R	TCGA-EE-A2M5	SKCM	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.1389
p.N314H	TCGA-EO-A3B0	UCEC	TCGA	FPVHLD	LIG_APCC_ABBA_1	0.0556
p.A323T	SIDM01608	Endometrial Carcinoma	GDSC	FPVHLD	LIG_APCC_ABBA_1	0.3056
p.P316Q	ACH-000749	Lung Cancer	CCLE	FPVHLD	LIG_APCC_ABBA_1	0.1111
p.P316Q	DMS-273	lung	COSMIC	FPVHLD	LIG_APCC_ABBA_1	0.1111
p.T328I	GEO	large_intestine	COSMIC	FPVHLD	LIG_APCC_ABBA_1	0.7078
p.P334S	SNU-C2B	large_intestine	COSMIC	FPVHLD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGM5	Fetuin-B	LIG_APCC_ABBA_1	324:329	FPVHLD	APC,CDC20,FZR1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons