DegronMD

Uniprot ID: Q9Y305

Source protein: Acyl-coenzyme A thioesterase 9, mitochondrial

Source gene: ACOT9

Class: LIG_APCC_ABBA_1

Location: 186:191

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5903

ASA_SCORE: 63.8

COIL: 0.4372

CONS_SCORE: 0.3056

DSS_SCORE: 0.1538

HELIX: 0.0113

FCONS_SCORE: 0.5842

RIG_SCORE: 0.8372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S177N	TCGA-B5-A1MX	UCEC	TCGA	FQLHGD	LIG_APCC_ABBA_1	0.0833
p.G199C	TCGA-ER-A19P	SKCM	TCGA	FQLHGD	LIG_APCC_ABBA_1	0.1111
p.E189K	TCGA-EY-A1GI	UCEC	TCGA	FQLHGD	LIG_APCC_ABBA_1	0.7022
p.T186M	DO6080	BRCA	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.7423
p.T186K	DO228978	LICA	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.7306
p.A192D	DO228971	LICA	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.3056
p.T200N	DO229028	LICA	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.0833
p.S187P	DO36388	READ	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.6752
p.P193H	DO47278	SKCM	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.2778
p.S185T	DO38731	STAD	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.3056
p.K190N	DO43186	UCEC	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.6918
p.A192T	DO41903	UCEC	ICGC	FQLHGD	LIG_APCC_ABBA_1	0.3056
p.Q193K	SIDM00845	Burkitt's Lymphoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	0.2778
p.Q193K	SIDM01519	Head and Neck Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	0.2778
p.H198R	SIDM00831	Head and Neck Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	0.1389
p.H198R	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	0.1389
p.H198R	SIDM00783	Colorectal Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	0.1389
p.V190A	SIDM00217	Colorectal Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	0.6936
p.V190A	SNU-1040	large_intestine	COSMIC	FQLHGD	LIG_APCC_ABBA_1	0.6936
p.T200A	ACH-000977	lymph_node	CCLE	FQLHGD	LIG_APCC_ABBA_1	0.0833
p.T200A	LNCaP-Clone-FGC	prostate	COSMIC	FQLHGD	LIG_APCC_ABBA_1	0.0833
p.V181A	ACH-000999	Colon/Colorectal Cancer	CCLE	FQLHGD	LIG_APCC_ABBA_1	0.1944
p.V181A	SNU-1040	large_intestine	COSMIC	FQLHGD	LIG_APCC_ABBA_1	0.1944
p.D191V	ACH-001369	Ovarian Cancer	CCLE	FQLHGD	LIG_APCC_ABBA_1	0.7785
p.M191T	NCI-H1651	lung	COSMIC	FQLHGD	LIG_APCC_ABBA_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y305	Acyl-coenzyme A thioesterase 9, mitochondrial	LIG_APCC_ABBA_1	186:191	FQLHGD	APC,CDC20,FZR1	0.5903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FQLHGD

Degron related mutations and impact score

Drug responses associated with ACOT9 mutations

All proteins holding degron of FQLHGD