DegronMD - Q9Y305(ACOT9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I34L	TCGA-A5-A1OF	UCEC	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1667
p.I34L	DO42568	UCEC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1667
p.R50Q	TCGA-AA-3864	COAD	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.R50Q	TCGA-AG-3892	READ	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.S177N	TCGA-B5-A1MX	UCEC	TCGA	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0833
p.K52T	TCGA-CA-6717	COAD	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222
p.K52T	SIDM00118	Colorectal Carcinoma	GDSC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222
p.K52T	HCC2998	large intestine	COSMIC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222
p.G199C	TCGA-ER-A19P	SKCM	TCGA	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1111
p.E189K	TCGA-EY-A1GI	UCEC	TCGA	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7022
p.P33S	DO1749	BRCA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1389
p.T186M	DO6080	BRCA	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7423
p.T52I	DO223732	CESC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222
p.R41Q	DO8490	COAD	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7329
p.R41Q	DO36394	READ	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7329
p.K43T	DO8264	COAD	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6195
p.K43T	DO222762	COCA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6195
p.K43T	ACH-001081	Colon/Colorectal Cancer	CCLE	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6195
p.K43T	HCC2998	large intestine	COSMIC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6195
p.P38H	DO222618	ESCA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.T186K	DO228978	LICA	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7306
p.A192D	DO228971	LICA	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.3056
p.T200N	DO229028	LICA	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0833
p.A40E	DO229032	LICA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7701
p.L57I	DO229031	LICA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.0833
p.C41Y	DO231590	LINC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7087
p.S187P	DO36388	READ	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6752
p.P193H	DO47278	SKCM	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2778
p.S185T	DO38731	STAD	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.3056
p.L31I	DO43306	UCEC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation substituting flanking lysine	0.1944
p.K190N	DO43186	UCEC	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6918
p.A192T	DO41903	UCEC	ICGC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.3056
p.E42D	DO41903	UCEC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6758
p.Q193K	SIDM00845	Burkitt's Lymphoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2778
p.Q193K	SIDM01519	Head and Neck Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2778
p.H198R	SIDM00831	Head and Neck Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1389
p.H198R	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1389
p.H198R	SIDM00783	Colorectal Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1389
p.V190A	SIDM00217	Colorectal Carcinoma	GDSC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6936
p.V190A	SNU-1040	large intestine	COSMIC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6936
p.T200A	ACH-000977	lymph node	CCLE	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0833
p.T200A	LNCaP-Clone-FGC	prostate	COSMIC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0833
p.V181A	ACH-000999	Colon/Colorectal Cancer	CCLE	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1944
p.V181A	SNU-1040	large intestine	COSMIC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1944
p.D191V	ACH-001369	Ovarian Cancer	CCLE	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7785
p.M191T	NCI-H1651	lung	COSMIC	FQLHGD	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACOT9

UniProt ID: Q9Y305

Entrez ID: 23597

Protein name: Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACOT9 in