DegronMD

Uniprot ID: Q9Y305

Source protein: Acyl-coenzyme A thioesterase 9, mitochondrial

Source gene: ACOT9

Class: DEG_APCC_DBOX_1

Location: 40:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5795

ASA_SCORE: 58.8556

COIL: 0.0334

CONS_SCORE: 0.2858

DSS_SCORE: 0.3472

HELIX: 0.9656

FCONS_SCORE: 1.1949

RIG_SCORE: 0.8102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I34L	TCGA-A5-A1OF	UCEC	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	0.1667
p.I34L	DO42568	UCEC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.1667
p.R50Q	TCGA-AA-3864	COAD	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	0.2778
p.R50Q	TCGA-AG-3892	READ	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	0.2778
p.K52T	TCGA-CA-6717	COAD	TCGA	VRDKLREIV	DEG_APCC_DBOX_1	0.2222
p.K52T	SIDM00118	Colorectal Carcinoma	GDSC	VRDKLREIV	DEG_APCC_DBOX_1	0.2222
p.K52T	HCC2998	large_intestine	COSMIC	VRDKLREIV	DEG_APCC_DBOX_1	0.2222
p.P33S	DO1749	BRCA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.1389
p.T52I	DO223732	CESC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.2222
p.R41Q	DO8490	COAD	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.7329
p.R41Q	DO36394	READ	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.7329
p.K43T	DO8264	COAD	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.6195
p.K43T	DO222762	COCA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.6195
p.K43T	ACH-001081	Colon/Colorectal Cancer	CCLE	VRDKLREIV	DEG_APCC_DBOX_1	0.6195
p.K43T	HCC2998	large_intestine	COSMIC	VRDKLREIV	DEG_APCC_DBOX_1	0.6195
p.P38H	DO222618	ESCA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.2778
p.A40E	DO229032	LICA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.7701
p.L57I	DO229031	LICA	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.0833
p.C41Y	DO231590	LINC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.7087
p.L31I	DO43306	UCEC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.1944
p.E42D	DO41903	UCEC	ICGC	VRDKLREIV	DEG_APCC_DBOX_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y305	Acyl-coenzyme A thioesterase 9, mitochondrial	DEG_APCC_DBOX_1	40:48	VRDKLREIV	APC,CDC20,FZR1	0.5795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons