DegronMD

Uniprot ID: O43823

Source protein: A-kinase anchor protein 8

Source gene: AKAP8

Class: LIG_APCC_ABBA_1

Location: 308:313

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 112.0833

COIL: 0.7107

CONS_SCORE: 0.598

DSS_SCORE: 0.6048

HELIX: 0.252

FCONS_SCORE: 1.0318

RIG_SCORE: 0.7702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L310P	TCGA-CM-6677	COAD	TCGA	FQLYEE	LIG_APCC_ABBA_1	0.6471
p.L310P	DO8570	COAD	ICGC	FQLYEE	LIG_APCC_ABBA_1	0.6471
p.P314A	TCGA-E1-A7YE	LGG	TCGA	FQLYEE	LIG_APCC_ABBA_1	0.3056
p.P314A	DO223667	LGG	ICGC	FQLYEE	LIG_APCC_ABBA_1	0.3056
p.G300D	DO229123	NKTL	ICGC	FQLYEE	LIG_APCC_ABBA_1	0.1111
p.G300D	SIDM02035	Colorectal Carcinoma	GDSC	FQLYEE	LIG_APCC_ABBA_1	0.1111
p.R320W	DO219878	SKCA	ICGC	FQLYEE	LIG_APCC_ABBA_1	0.1389
p.R305W	SIDM00500	Colorectal Carcinoma	GDSC	FQLYEE	LIG_APCC_ABBA_1	0.25
p.R305W	ACH-000959	Colon/Colorectal Cancer	CCLE	FQLYEE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43823	A-kinase anchor protein 8	LIG_APCC_ABBA_1	308:313	FQLYEE	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons