DegronMD - O43823(AKAP8)

FUNCTION: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L310P	TCGA-CM-6677	COAD	TCGA	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.6471
p.L310P	DO8570	COAD	ICGC	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation altering degron motif	0.6471
p.P314A	TCGA-E1-A7YE	LGG	TCGA	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.P314A	DO223667	LGG	ICGC	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.V211M	TCGA-G4-6588	COAD	TCGA	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.1111
p.V211M	DO10140	COAD	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.1111
p.E226K	DO7436	CLLE	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation altering degron motif	0.7022
p.P212S	DO228623	LICA	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.1389
p.G232E	DO220852	MELA	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.1667
p.G300D	DO229123	NKTL	ICGC	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.G300D	SIDM02035	Colorectal Carcinoma	GDSC	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.R320W	DO219878	SKCA	ICGC	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1389
p.S221C	SIDM00752	Non-Cancerous	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation altering degron motif	0.643
p.S221C	ACH-000904	Lung Cancer	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation altering degron motif	0.643
p.S221C	ACH-002365	Non-Cancerous	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation altering degron motif	0.643
p.R233Q	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.1389
p.R233Q	ACH-002275	Leukemia	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.1389
p.L235P	SIDM01612	Endometrial Carcinoma	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.0833
p.L235P	ACH-000946	Endometrial/Uterine Cancer	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.0833
p.P209L	SIDM01611	Endometrial Carcinoma	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.0556
p.P209L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	219:226	Mutation rewiring degron network	0.0556
p.R305W	SIDM00500	Colorectal Carcinoma	GDSC	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.25
p.R305W	ACH-000959	Colon/Colorectal Cancer	CCLE	FQLYEE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.25

Kaplan plot for AKAP8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP8

UniProt ID: O43823

Entrez ID: 10270

Protein name: A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP8 in