DegronMD

Uniprot ID: O43823

Source protein: A-kinase anchor protein 8

Source gene: AKAP8

Class: DEG_SCF_FBW7_2

Location: 219:226

E3 ligase: FBXW7

DEGRON score: 0.9316

ASA_SCORE: 66.475

COIL: 0.8303

CONS_SCORE: 0.5111

DSS_SCORE: 0.4863

HELIX: 0.1256

FCONS_SCORE: 0.8973

RIG_SCORE: 0.6896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V211M	TCGA-G4-6588	COAD	TCGA	PLSTPWNE	DEG_SCF_FBW7_2	0.1111
p.V211M	DO10140	COAD	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	0.1111
p.E226K	DO7436	CLLE	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	0.7022
p.P212S	DO228623	LICA	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	0.1389
p.G232E	DO220852	MELA	ICGC	PLSTPWNE	DEG_SCF_FBW7_2	0.1667
p.S221C	SIDM00752	Non-Cancerous	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	0.643
p.S221C	ACH-000904	Lung Cancer	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	0.643
p.S221C	ACH-002365	Non-Cancerous	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	0.643
p.R233Q	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	0.1389
p.R233Q	ACH-002275	Leukemia	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	0.1389
p.L235P	SIDM01612	Endometrial Carcinoma	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	0.0833
p.L235P	ACH-000946	Endometrial/Uterine Cancer	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	0.0833
p.P209L	SIDM01611	Endometrial Carcinoma	GDSC	PLSTPWNE	DEG_SCF_FBW7_2	0.0556
p.P209L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PLSTPWNE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43823	A-kinase anchor protein 8	DEG_SCF_FBW7_2	219:226	PLSTPWNE	FBXW7	0.9316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons