DegronMD

Uniprot ID: Q9C0D4

Source protein: Zinc finger protein 518B

Source gene: ZNF518B

Class: DEG_MDM2_SWIB_1

Location: 252:260

E3 ligase: MDM2

DEGRON score: 0.9409

ASA_SCORE: 85.2444

COIL: 0.6373

CONS_SCORE: 0.555

DSS_SCORE: 0.4639

HELIX: 0.2983

FCONS_SCORE: 1.2335

RIG_SCORE: 0.7418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S261P	TCGA-06-5416	GBM	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	0.3056
p.S261P	DO10880	GBM	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.3056
p.D258H	TCGA-A2-A0YK	BRCA	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	0.6577
p.D258H	DO2836	BRCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.6577
p.S246F	TCGA-EE-A2MS	SKCM	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	0.1667
p.S246F	DO37567	SKCM	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.1667
p.D270A	TCGA-FI-A2D0	UCEC	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	0.0556
p.D270A	DO43891	UCEC	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.0556
p.Q253E	TCGA-ZF-A9RL	BLCA	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	0.5633
p.Q253E	DO219078	BLCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.5633
p.T250S	TCGA-ZF-AA4W	BLCA	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.T250S	DO219089	BLCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO229016	COCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO229005	COCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO234285	ESAD	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO230659	LAML	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO225404	LAML	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO231140	LAML	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.G262A	DO230993	LUSC	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2778
p.S257P	DO234340	ESAD	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.6752
p.Q253H	DO234285	ESAD	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.647
p.R249W	SIDM00151	Ovarian Carcinoma	GDSC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.25
p.R249W	ACH-000966	Ovarian Cancer	CCLE	FQNKWSDQL	DEG_MDM2_SWIB_1	0.25
p.R249W	IGROV-1	ovary	COSMIC	FQNKWSDQL	DEG_MDM2_SWIB_1	0.25
p.P248L	ACH-002041	Thyroid Cancer	CCLE	FQNKWSDQL	DEG_MDM2_SWIB_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D4	Zinc finger protein 518B	DEG_MDM2_SWIB_1	252:260	FQNKWSDQL	MDM2	0.9409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons