DegronMD - Q9C0D4(ZNF518B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E648K	TCGA-06-5416	GBM	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.7022
p.E648K	TCGA-AP-A056	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.7022
p.E648K	DO10880	GBM	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.7022
p.E648K	DO43971	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.7022
p.S261P	TCGA-06-5416	GBM	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.3056
p.S261P	DO10880	GBM	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.3056
p.K658R	TCGA-43-7656	LUSC	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation blocking ubiquitination signal	0.5556
p.K658R	DO26424	LUSC	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation blocking ubiquitination signal	0.5556
p.D258H	TCGA-A2-A0YK	BRCA	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation altering degron motif	0.6577
p.D258H	DO2836	BRCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation altering degron motif	0.6577
p.G630D	TCGA-AX-A1CE	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.0556
p.G630D	DO42280	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.0556
p.S638C	TCGA-D8-A1Y0	BRCA	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.2778
p.S638C	DO3376	BRCA	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.2778
p.S246F	TCGA-EE-A2MS	SKCM	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.1667
p.S246F	DO37567	SKCM	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.1667
p.S640G	TCGA-EI-6917	READ	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.6993
p.S640G	DO36881	READ	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.6993
p.G630V	TCGA-EY-A215	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.0556
p.G630V	DO42665	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.0556
p.D270A	TCGA-FI-A2D0	UCEC	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.0556
p.D270A	DO43891	UCEC	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.0556
p.V632I	TCGA-FI-A2D5	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1111
p.V632I	DO41331	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1111
p.T656M	TCGA-HU-A4G9	STAD	TCGA	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1667
p.T656M	DO47789	STAD	ICGC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1667
p.Q253E	TCGA-ZF-A9RL	BLCA	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation altering degron motif	0.5633
p.Q253E	DO219078	BLCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation altering degron motif	0.5633
p.T250S	TCGA-ZF-AA4W	BLCA	TCGA	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.T250S	DO219089	BLCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO229016	COCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO229005	COCA	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO234285	ESAD	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO230659	LAML	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO225404	LAML	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO231140	LAML	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.G262A	DO230993	LUSC	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2778
p.S257P	DO234340	ESAD	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation altering degron motif	0.6752
p.Q253H	DO234285	ESAD	ICGC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation altering degron motif	0.647
p.S635A	SIDM01265	Plasma Cell Myeloma	GDSC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1944
p.S654R	SIDM00281	Other Solid Cancers	GDSC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.2222
p.S654R	ACH-002100	Skin Cancer	CCLE	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.2222
p.S654R	DJM-1	skin	COSMIC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.2222
p.R249W	SIDM00151	Ovarian Carcinoma	GDSC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.25
p.R249W	ACH-000966	Ovarian Cancer	CCLE	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.25
p.R249W	IGROV-1	ovary	COSMIC	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.25
p.S635T	SIDM00118	Colorectal Carcinoma	GDSC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1944
p.S635T	ACH-001081	Colon/Colorectal Cancer	CCLE	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1944
p.S635T	HCC2998	large intestine	COSMIC	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation rewiring degron network	0.1944
p.P248L	ACH-002041	Thyroid Cancer	CCLE	FQNKWSDQL	DEG_MDM2_SWIB_1	252:260	Mutation rewiring degron network	0.2222
p.V646F	ACH-002464	Non-Cancerous	CCLE	SSGSENVPEGI	DEG_COP1_1	640:650	Mutation altering degron motif	0.7068

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF518B

UniProt ID: Q9C0D4

Entrez ID: 85460

Protein name: Zinc finger protein 518B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF518B in