DegronMD

Uniprot ID: Q9C0D4

Source protein: Zinc finger protein 518B

Source gene: ZNF518B

Class: DEG_COP1_1

Location: 640:650

E3 ligase: COP1

DEGRON score: 0.925

ASA_SCORE: 73.2909

COIL: 0.7653

CONS_SCORE: 0.6588

DSS_SCORE: 0.3955

HELIX: 0.0511

FCONS_SCORE: 0.9439

RIG_SCORE: 0.659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E648K	TCGA-06-5416	GBM	TCGA	SSGSENVPEGI	DEG_COP1_1	0.7022
p.E648K	TCGA-AP-A056	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	0.7022
p.E648K	DO10880	GBM	ICGC	SSGSENVPEGI	DEG_COP1_1	0.7022
p.E648K	DO43971	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	0.7022
p.K658R	TCGA-43-7656	LUSC	TCGA	SSGSENVPEGI	DEG_COP1_1	0.5556
p.K658R	DO26424	LUSC	ICGC	SSGSENVPEGI	DEG_COP1_1	0.5556
p.G630D	TCGA-AX-A1CE	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	0.0556
p.G630D	DO42280	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	0.0556
p.S638C	TCGA-D8-A1Y0	BRCA	TCGA	SSGSENVPEGI	DEG_COP1_1	0.2778
p.S638C	DO3376	BRCA	ICGC	SSGSENVPEGI	DEG_COP1_1	0.2778
p.S640G	TCGA-EI-6917	READ	TCGA	SSGSENVPEGI	DEG_COP1_1	0.6993
p.S640G	DO36881	READ	ICGC	SSGSENVPEGI	DEG_COP1_1	0.6993
p.G630V	TCGA-EY-A215	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	0.0556
p.G630V	DO42665	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	0.0556
p.V632I	TCGA-FI-A2D5	UCEC	TCGA	SSGSENVPEGI	DEG_COP1_1	0.1111
p.V632I	DO41331	UCEC	ICGC	SSGSENVPEGI	DEG_COP1_1	0.1111
p.T656M	TCGA-HU-A4G9	STAD	TCGA	SSGSENVPEGI	DEG_COP1_1	0.1667
p.T656M	DO47789	STAD	ICGC	SSGSENVPEGI	DEG_COP1_1	0.1667
p.S635A	SIDM01265	Plasma Cell Myeloma	GDSC	SSGSENVPEGI	DEG_COP1_1	0.1944
p.S654R	SIDM00281	Other Solid Cancers	GDSC	SSGSENVPEGI	DEG_COP1_1	0.2222
p.S654R	ACH-002100	Skin Cancer	CCLE	SSGSENVPEGI	DEG_COP1_1	0.2222
p.S654R	DJM-1	skin	COSMIC	SSGSENVPEGI	DEG_COP1_1	0.2222
p.S635T	SIDM00118	Colorectal Carcinoma	GDSC	SSGSENVPEGI	DEG_COP1_1	0.1944
p.S635T	ACH-001081	Colon/Colorectal Cancer	CCLE	SSGSENVPEGI	DEG_COP1_1	0.1944
p.S635T	HCC2998	large_intestine	COSMIC	SSGSENVPEGI	DEG_COP1_1	0.1944
p.V646F	ACH-002464	Non-Cancerous	CCLE	SSGSENVPEGI	DEG_COP1_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D4	Zinc finger protein 518B	DEG_COP1_1	640:650	SSGSENVPEGI	COP1	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSGSENVPEGI

Degron related mutations and impact score

Drug responses associated with ZNF518B mutations

All proteins holding degron of SSGSENVPEGI