DegronMD

Uniprot ID: Q5T124

Source protein: UBX domain-containing protein 11

Source gene: UBXN11

Class: LIG_APCC_ABBA_1

Location: 249:254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9298

ASA_SCORE: 53.85

COIL: 0.869

CONS_SCORE: 0.673

DSS_SCORE: 0.2918

HELIX: 0.0302

FCONS_SCORE: 1.0746

RIG_SCORE: 0.79

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R239Q	TCGA-AG-A02N	READ	TCGA	FQPFYD	LIG_APCC_ABBA_1	0.0556
p.P255H	TCGA-G4-6628	COAD	TCGA	FQPFYD	LIG_APCC_ABBA_1	0.3056
p.Q258P	DO225169	BRCA	ICGC	FQPFYD	LIG_APCC_ABBA_1	0.2222
p.R256C	DO50336	ESAD	ICGC	FQPFYD	LIG_APCC_ABBA_1	0.2778
p.M243L	DO45139	LIRI	ICGC	FQPFYD	LIG_APCC_ABBA_1	0.1667
p.R256H	DO223726	LUSC	ICGC	FQPFYD	LIG_APCC_ABBA_1	0.2778
p.L261F	SIDM00003	Melanoma	GDSC	FQPFYD	LIG_APCC_ABBA_1	0.1389
p.L261F	ACH-000884	Skin Cancer	CCLE	FQPFYD	LIG_APCC_ABBA_1	0.1389
p.L261F	ACH-002159	Skin Cancer	CCLE	FQPFYD	LIG_APCC_ABBA_1	0.1389
p.L261F	M14	skin	COSMIC	FQPFYD	LIG_APCC_ABBA_1	0.1389
p.R259C	SIDM00414	Bladder Carcinoma	GDSC	FQPFYD	LIG_APCC_ABBA_1	0.1944
p.R259C	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	FQPFYD	LIG_APCC_ABBA_1	0.1944
p.R259C	SIDM01725	Non-Cancerous	GDSC	FQPFYD	LIG_APCC_ABBA_1	0.1944
p.A259V	ES7	bone	COSMIC	FQPFYD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T124	UBX domain-containing protein 11	LIG_APCC_ABBA_1	249:254	FQPFYD	APC,CDC20,FZR1	0.9298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons