DegronMD - Q5T124(UBXN11)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D33N	TCGA-44-6144	LUAD	TCGA	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6932
p.D33N	DO24190	LUAD	ICGC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6932
p.E19K	TCGA-63-A5MB	LUSC	TCGA	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0833
p.E19K	DO52018	LUSC	ICGC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0833
p.R239Q	TCGA-AG-A02N	READ	TCGA	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.0556
p.R29H	TCGA-AX-A1CE	UCEC	TCGA	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.7133
p.R29H	DO42280	UCEC	ICGC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.7133
p.P255H	TCGA-G4-6628	COAD	TCGA	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.3056
p.Q258P	DO225169	BRCA	ICGC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.2222
p.R256C	DO50336	ESAD	ICGC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.2778
p.A30V	DO234336	ESAD	ICGC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6936
p.M243L	DO45139	LIRI	ICGC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1667
p.R256H	DO223726	LUSC	ICGC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.2778
p.H38Y	DO220851	MELA	ICGC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.1944
p.G24E	SIDM00422	Hodgkin's Lymphoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.G24E	SIDM01168	Colorectal Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.G24E	SIDM00092	Ovarian Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.G24E	SIDM00665	Gastric Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.G24E	SIDM00225	Melanoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.G24E	SIDM01746	Osteosarcoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.R25K	SIDM00535	Chondrosarcoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.R25K	SIDM00616	Hepatocellular Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.R25K	ACH-000476	Liver Cancer	CCLE	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.R25K	ACH-001519	Bone Cancer	CCLE	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.R25K	H-EMC-SS	bone	COSMIC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.R25K	JHH-4	liver	COSMIC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.25
p.L261F	SIDM00003	Melanoma	GDSC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1389
p.L261F	ACH-000884	Skin Cancer	CCLE	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1389
p.L261F	ACH-002159	Skin Cancer	CCLE	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1389
p.L261F	M14	skin	COSMIC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1389
p.R259C	SIDM00414	Bladder Carcinoma	GDSC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1944
p.R259C	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1944
p.R259C	SIDM01725	Non-Cancerous	GDSC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1944
p.R29C	SIDM00673	Breast Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.719
p.R29C	ACH-000668	Breast Cancer	CCLE	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.719
p.R29C	HCC70	breast	COSMIC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.719
p.L18F	M14	skin	COSMIC	IRIYGD	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0556
p.A259V	ES7	bone	COSMIC	FQPFYD	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBXN11

UniProt ID: Q5T124

Entrez ID: 91544

Protein name: UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for UBXN11 in