DegronMD

Uniprot ID: Q5T124

Source protein: UBX domain-containing protein 11

Source gene: UBXN11

Class: LIG_APCC_ABBA_1

Location: 28:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9985

ASA_SCORE: 81.8667

COIL: 0.875

CONS_SCORE: 0.3054

DSS_SCORE: 0.5563

HELIX: 0.0225

FCONS_SCORE: 0.9049

RIG_SCORE: 0.7438

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R29C	SIDM00673	Breast Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.719
p.R29C	ACH-000668	Breast Cancer	CCLE	IRIYGD	LIG_APCC_ABBA_1	0.719
p.R29C	HCC70	breast	COSMIC	IRIYGD	LIG_APCC_ABBA_1	0.719
p.R29H	TCGA-AX-A1CE	UCEC	TCGA	IRIYGD	LIG_APCC_ABBA_1	0.7133
p.R29H	DO42280	UCEC	ICGC	IRIYGD	LIG_APCC_ABBA_1	0.7133
p.A30V	DO234336	ESAD	ICGC	IRIYGD	LIG_APCC_ABBA_1	0.6936
p.D33N	TCGA-44-6144	LUAD	TCGA	IRIYGD	LIG_APCC_ABBA_1	0.6932
p.D33N	DO24190	LUAD	ICGC	IRIYGD	LIG_APCC_ABBA_1	0.6932
p.R25K	SIDM00535	Chondrosarcoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.25
p.R25K	SIDM00616	Hepatocellular Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.25
p.R25K	ACH-000476	Liver Cancer	CCLE	IRIYGD	LIG_APCC_ABBA_1	0.25
p.R25K	ACH-001519	Bone Cancer	CCLE	IRIYGD	LIG_APCC_ABBA_1	0.25
p.R25K	H-EMC-SS	bone	COSMIC	IRIYGD	LIG_APCC_ABBA_1	0.25
p.R25K	JHH-4	liver	COSMIC	IRIYGD	LIG_APCC_ABBA_1	0.25
p.G24E	SIDM00422	Hodgkin's Lymphoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.2222
p.G24E	SIDM01168	Colorectal Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.2222
p.G24E	SIDM00092	Ovarian Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.2222
p.G24E	SIDM00665	Gastric Carcinoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.2222
p.G24E	SIDM00225	Melanoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.2222
p.G24E	SIDM01746	Osteosarcoma	GDSC	IRIYGD	LIG_APCC_ABBA_1	0.2222
p.H38Y	DO220851	MELA	ICGC	IRIYGD	LIG_APCC_ABBA_1	0.1944
p.E19K	TCGA-63-A5MB	LUSC	TCGA	IRIYGD	LIG_APCC_ABBA_1	0.0833
p.E19K	DO52018	LUSC	ICGC	IRIYGD	LIG_APCC_ABBA_1	0.0833
p.L18F	M14	skin	COSMIC	IRIYGD	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T124	UBX domain-containing protein 11	LIG_APCC_ABBA_1	28:33	IRIYGD	APC,CDC20,FZR1	0.9985	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons