DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IRIYGD
Uniprot ID:
Q5T124
Source protein:
UBX domain-containing protein 11
Source gene:
UBXN11
Class:
LIG_APCC_ABBA_1
Location:
28:33
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9985
ASA_SCORE:
81.8667
COIL:
0.875
CONS_SCORE:
0.3054
DSS_SCORE:
0.5563
HELIX:
0.0225
FCONS_SCORE:
0.9049
RIG_SCORE:
0.7438
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D33N
TCGA-44-6144
LUAD
TCGA
IRIYGD
LIG_APCC_ABBA_1
0.6932
p.D33N
DO24190
LUAD
ICGC
IRIYGD
LIG_APCC_ABBA_1
0.6932
p.E19K
TCGA-63-A5MB
LUSC
TCGA
IRIYGD
LIG_APCC_ABBA_1
0.0833
p.E19K
DO52018
LUSC
ICGC
IRIYGD
LIG_APCC_ABBA_1
0.0833
p.R29H
TCGA-AX-A1CE
UCEC
TCGA
IRIYGD
LIG_APCC_ABBA_1
0.7133
p.R29H
DO42280
UCEC
ICGC
IRIYGD
LIG_APCC_ABBA_1
0.7133
p.A30V
DO234336
ESAD
ICGC
IRIYGD
LIG_APCC_ABBA_1
0.6936
p.H38Y
DO220851
MELA
ICGC
IRIYGD
LIG_APCC_ABBA_1
0.1944
p.G24E
SIDM00422
Hodgkin's Lymphoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.2222
p.G24E
SIDM01168
Colorectal Carcinoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.2222
p.G24E
SIDM00092
Ovarian Carcinoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.2222
p.G24E
SIDM00665
Gastric Carcinoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.2222
p.G24E
SIDM00225
Melanoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.2222
p.G24E
SIDM01746
Osteosarcoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.2222
p.R25K
SIDM00535
Chondrosarcoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.25
p.R25K
SIDM00616
Hepatocellular Carcinoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.25
p.R25K
ACH-000476
Liver Cancer
CCLE
IRIYGD
LIG_APCC_ABBA_1
0.25
p.R25K
ACH-001519
Bone Cancer
CCLE
IRIYGD
LIG_APCC_ABBA_1
0.25
p.R25K
H-EMC-SS
bone
COSMIC
IRIYGD
LIG_APCC_ABBA_1
0.25
p.R25K
JHH-4
liver
COSMIC
IRIYGD
LIG_APCC_ABBA_1
0.25
p.R29C
SIDM00673
Breast Carcinoma
GDSC
IRIYGD
LIG_APCC_ABBA_1
0.719
p.R29C
ACH-000668
Breast Cancer
CCLE
IRIYGD
LIG_APCC_ABBA_1
0.719
p.R29C
HCC70
breast
COSMIC
IRIYGD
LIG_APCC_ABBA_1
0.719
p.L18F
M14
skin
COSMIC
IRIYGD
LIG_APCC_ABBA_1
0.0556
Drug responses associated with UBXN11 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IRIYGD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5T124
UBX domain-containing protein 11
LIG_APCC_ABBA_1
28:33
IRIYGD
APC,CDC20,FZR1
0.9985
More...