DegronMD

Uniprot ID: P08514

Source protein: Integrin alpha-IIb

Source gene: ITGA2B

Class: DEG_APCC_DBOX_1

Location: 589:597

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.535

ASA_SCORE: 52.9889

COIL: 0.5307

CONS_SCORE: 0.5858

DSS_SCORE: 0.1684

HELIX: 0.0847

FCONS_SCORE: 1.4475

RIG_SCORE: 0.8336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V597E	TCGA-64-1679	LUAD	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	0.6582
p.V597E	DO26200	LUAD	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.6582
p.R590Q	TCGA-CG-5721	STAD	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	0.7329
p.R590Q	DO38192	STAD	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.7329
p.R590Q	SIDM00220	Ovarian Carcinoma	GDSC	FRDKLSPIV	DEG_APCC_DBOX_1	0.7329
p.R590Q	OC-314	ovary	COSMIC	FRDKLSPIV	DEG_APCC_DBOX_1	0.7329
p.S603F	TCGA-D3-A3C3	SKCM	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	0.1667
p.S603F	DO222702	MELA	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.1667
p.S603F	DO47667	SKCM	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.1667
p.T607M	TCGA-RD-A7C1	STAD	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	0.0556
p.T607M	DO45299	LIRI	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.0556
p.T607M	DO50132	STAD	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.0556
p.M580I	TCGA-RP-A695	SKCM	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	0.0833
p.M580I	DO51270	SKCM	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.0833
p.A587T	DO229177	LMS	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.2778
p.R590W	DO35083	PACA	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	0.8634
p.D591G	SIDM01958	Esophageal Carcinoma	GDSC	FRDKLSPIV	DEG_APCC_DBOX_1	0.6087
p.D591V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FRDKLSPIV	DEG_APCC_DBOX_1	0.6674
p.D591V	ACH-000929	Lung Cancer	CCLE	FRDKLSPIV	DEG_APCC_DBOX_1	0.6674
p.D591V	NCI-H2110	lung	COSMIC	FRDKLSPIV	DEG_APCC_DBOX_1	0.6674

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08514	Integrin alpha-IIb	DEG_APCC_DBOX_1	589:597	FRDKLSPIV	APC,CDC20,FZR1	0.535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons