DegronMD - P08514(ITGA2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V597E	TCGA-64-1679	LUAD	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6582
p.V597E	DO26200	LUAD	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6582
p.H622R	TCGA-B7-A5TI	STAD	TCGA	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.2778
p.H622R	DO222328	STAD	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.2778
p.V630I	TCGA-BH-A0HI	BRCA	TCGA	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.0556
p.V630I	DO5801	BRCA	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.0556
p.R590Q	TCGA-CG-5721	STAD	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7329
p.R590Q	DO38192	STAD	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7329
p.R590Q	SIDM00220	Ovarian Carcinoma	GDSC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7329
p.R590Q	OC-314	ovary	COSMIC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.7329
p.S603F	TCGA-D3-A3C3	SKCM	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.1667
p.S603F	DO222702	MELA	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.1667
p.S603F	DO47667	SKCM	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.1667
p.H622Y	TCGA-EE-A29E	SKCM	TCGA	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.2778
p.H622Y	DO37831	SKCM	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.2778
p.T607M	TCGA-RD-A7C1	STAD	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.0556
p.T607M	TCGA-RD-A7C1	STAD	TCGA	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.1111
p.T607M	DO45299	LIRI	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.0556
p.T607M	DO45299	LIRI	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.1111
p.T607M	DO50132	STAD	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.0556
p.T607M	DO50132	STAD	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.1111
p.M580I	TCGA-RP-A695	SKCM	TCGA	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.0833
p.M580I	DO51270	SKCM	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.0833
p.R628Q	DO230309	COCA	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation rewiring degron network	0.1111
p.H618R	DO48728	LIRI	ICGC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation altering degron motif	0.8244
p.A587T	DO229177	LMS	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation rewiring degron network	0.2778
p.R590W	DO35083	PACA	ICGC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.8634
p.D591G	SIDM01958	Esophageal Carcinoma	GDSC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6087
p.D591V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6674
p.D591V	ACH-000929	Lung Cancer	CCLE	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6674
p.D591V	NCI-H2110	lung	COSMIC	FRDKLSPIV	DEG_APCC_DBOX_1	589:597	Mutation altering degron motif	0.6674
p.V616M	SIDM00720	Mesothelioma	GDSC	VVLHGD	LIG_APCC_ABBA_1	615:620	Mutation altering degron motif	0.6097

Kaplan plot for ITGA2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA2B

UniProt ID: P08514

Entrez ID: 3674

Protein name: Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA2B in