DegronMD

Uniprot ID: P08514

Source protein: Integrin alpha-IIb

Source gene: ITGA2B

Class: LIG_APCC_ABBA_1

Location: 615:620

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9929

ASA_SCORE: 71

COIL: 0.8163

CONS_SCORE: 0.4113

DSS_SCORE: 0.4196

HELIX: 0.0338

FCONS_SCORE: 0.9705

RIG_SCORE: 0.758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H622R	TCGA-B7-A5TI	STAD	TCGA	VVLHGD	LIG_APCC_ABBA_1	0.2778
p.H622R	DO222328	STAD	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.2778
p.V630I	TCGA-BH-A0HI	BRCA	TCGA	VVLHGD	LIG_APCC_ABBA_1	0.0556
p.V630I	DO5801	BRCA	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.0556
p.H622Y	TCGA-EE-A29E	SKCM	TCGA	VVLHGD	LIG_APCC_ABBA_1	0.2778
p.H622Y	DO37831	SKCM	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.2778
p.T607M	TCGA-RD-A7C1	STAD	TCGA	VVLHGD	LIG_APCC_ABBA_1	0.1111
p.T607M	DO45299	LIRI	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.1111
p.T607M	DO50132	STAD	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.1111
p.R628Q	DO230309	COCA	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.1111
p.H618R	DO48728	LIRI	ICGC	VVLHGD	LIG_APCC_ABBA_1	0.8244
p.V616M	SIDM00720	Mesothelioma	GDSC	VVLHGD	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08514	Integrin alpha-IIb	LIG_APCC_ABBA_1	615:620	VVLHGD	APC,CDC20,FZR1	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons