DegronMD

Uniprot ID: P35612

Source protein: Beta-adducin

Source gene: ADD2

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9891

ASA_SCORE: 48.3444

COIL: 0.0102

CONS_SCORE: 0.5765

DSS_SCORE: 0.3915

HELIX: 0.9889

FCONS_SCORE: 1.3397

RIG_SCORE: 0.7992

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L67V	ACH-000128	Brain Cancer	CCLE	FREELEGLI	DEG_APCC_DBOX_1	0.6765
p.E65K	TCGA-GN-A26C	SKCM	TCGA	FREELEGLI	DEG_APCC_DBOX_1	0.591
p.E65K	DO37782	SKCM	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.591
p.E66K	DO222662	MELA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.591
p.L70V	SIDM01569	Hepatocellular Carcinoma	GDSC	FREELEGLI	DEG_APCC_DBOX_1	0.5654
p.L70V	ACH-000734	Liver Cancer	CCLE	FREELEGLI	DEG_APCC_DBOX_1	0.5654
p.E65Q	DO222474	ESCA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.5633
p.P61L	SIDM01228	Melanoma	GDSC	FREELEGLI	DEG_APCC_DBOX_1	0.2778
p.P61L	CHL-1	skin	COSMIC	FREELEGLI	DEG_APCC_DBOX_1	0.2778
p.K77R	ACH-002287	Colon/Colorectal Cancer	CCLE	FREELEGLI	DEG_APCC_DBOX_1	0.2778
p.K77R	NCI-H630	large_intestine	COSMIC	FREELEGLI	DEG_APCC_DBOX_1	0.2778
p.P77L	CHL-1	skin	COSMIC	FREELEGLI	DEG_APCC_DBOX_1	0.2778
p.Q74K	TCGA-55-A492	LUAD	TCGA	FREELEGLI	DEG_APCC_DBOX_1	0.25
p.Q74K	DO23708	LUAD	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.25
p.Q74H	TCGA-DU-6392	LGG	TCGA	FREELEGLI	DEG_APCC_DBOX_1	0.25
p.Q74H	DO22237	LGG	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.25
p.L58Q	DO229234	THCA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.1944
p.G78R	TCGA-EE-A2MS	SKCM	TCGA	FREELEGLI	DEG_APCC_DBOX_1	0.1389
p.G78R	DO37567	SKCM	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.1389
p.M56I	TCGA-W3-AA1R	SKCM	TCGA	FREELEGLI	DEG_APCC_DBOX_1	0.1389
p.M56I	DO51275	SKCM	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.1389
p.M56V	DO229257	THCA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.1389
p.R53H	DO233936	GACA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	0.0556

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35612	Beta-adducin	DEG_APCC_DBOX_1	63:71	FREELEGLI	APC,CDC20,FZR1	0.9891	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons