DegronMD - P35612(ADD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P13L	TCGA-12-0662	GBM	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.2222
p.P13L	DO11358	GBM	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.2222
p.Q74K	TCGA-55-A492	LUAD	TCGA	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.Q74K	DO23708	LUAD	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.E3K	TCGA-A6-5657	COAD	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	TCGA-CG-5724	STAD	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	TCGA-D9-A1JW	SKCM	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	TCGA-OR-A5JS	ACC	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	DO10459	COAD	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	DO37786	SKCM	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	DO38847	STAD	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	SIDM00251	Gastric Carcinoma	GDSC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	ACH-000949	Gastric Cancer	CCLE	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.E3K	TGBC11TKB	stomach	COSMIC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7022
p.F485C	TCGA-AA-3510	COAD	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.3056
p.F485C	DO7783	COAD	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.3056
p.T5M	TCGA-AA-A02O	COAD	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7423
p.T5M	DO9226	COAD	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7423
p.T5M	SIDM01554	Mesothelioma	GDSC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7423
p.T5M	ACH-000331	Lung Cancer	CCLE	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7423
p.R478C	TCGA-AJ-A3EL	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	TCGA-BS-A0UF	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	TCGA-DK-A6AW	BLCA	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	DO48566	BLCA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	DO220902	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	DO222908	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	DO41542	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478C	DO41488	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.P476L	TCGA-AX-A1CE	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.0556
p.P476L	TCGA-FW-A3R5	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.0556
p.P476L	DO37406	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.0556
p.P476L	DO42280	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.0556
p.P15S	TCGA-BF-A3DM	SKCM	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1667
p.P15S	DO48667	SKCM	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1667
p.G17W	TCGA-D3-A2JC	SKCM	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1111
p.G17W	DO47578	SKCM	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1111
p.P492H	TCGA-D3-A3C6	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.3056
p.P492H	DO52512	EOPC	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.3056
p.P492H	DO37507	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.3056
p.Q74H	TCGA-DU-6392	LGG	TCGA	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.Q74H	DO22237	LGG	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.E480K	TCGA-EE-A2GR	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	TCGA-ER-A19E	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	TCGA-W3-AA1R	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	DO222710	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	DO222847	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	DO37996	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	DO47542	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	DO51275	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	SIDM00498	Colorectal Carcinoma	GDSC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	ACH-000970	Colon/Colorectal Cancer	CCLE	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E480K	SNU-C5	large intestine	COSMIC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.G78R	TCGA-EE-A2MS	SKCM	TCGA	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.G78R	DO37567	SKCM	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.R478H	TCGA-FI-A2D5	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.R478H	DO41331	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1111
p.P19L	TCGA-FR-A726	SKCM	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.0556
p.P19L	DO48665	SKCM	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.0556
p.E65K	TCGA-GN-A26C	SKCM	TCGA	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.591
p.E65K	DO37782	SKCM	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.591
p.M498I	TCGA-JW-A5VL	CESC	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1389
p.M498I	DO49976	CESC	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1389
p.T5A	TCGA-O2-A52Q	LUSC	TCGA	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7139
p.T5A	DO219219	LUSC	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7139
p.T5A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7139
p.T5A	ACH-002101	Lung Cancer	CCLE	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7139
p.T5A	EMC-BAC-1	lung	COSMIC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7139
p.M56I	TCGA-W3-AA1R	SKCM	TCGA	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.M56I	DO51275	SKCM	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.P487S	TCGA-WS-AB45	COAD	TCGA	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation altering degron motif	0.5641
p.P487S	DO51734	COAD	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation altering degron motif	0.5641
p.E497D	DO218411	BTCA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1667
p.E65Q	DO222474	ESCA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5633
p.R53H	DO233936	GACA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0556
p.D491G	DO228280	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation altering degron motif	0.7198
p.E3A	DO228913	LICA	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.7701
p.Q484K	DO228952	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.2778
p.L496M	DO228978	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1944
p.N500K	DO229026	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.0833
p.E66K	DO222662	MELA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.591
p.A10D	DO50678	ORCA	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.3056
p.G15R	DO31624	OV	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1667
p.G15R	M14	skin	COSMIC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1667
p.G15R	NCI-H2342	lung	COSMIC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1667
p.A9V	DO232224	PBCA	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.5825
p.A9V	GAK	skin	COSMIC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.5825
p.G15E	DO51298	SKCM	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.1667
p.M56V	DO229257	THCA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.L58Q	DO229234	THCA	ICGC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1944
p.R3C	DO42713	UCEC	ICGC	SEETVPEA	DEG_COP1_1	2:9	Mutation altering degron motif	0.8301
p.P61L	SIDM01228	Melanoma	GDSC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.P61L	CHL-1	skin	COSMIC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.L70V	SIDM01569	Hepatocellular Carcinoma	GDSC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.L70V	ACH-000734	Liver Cancer	CCLE	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.L67V	ACH-000128	Brain Cancer	CCLE	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6765
p.K77R	ACH-002287	Colon/Colorectal Cancer	CCLE	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation substituting flanking lysine	0.2778
p.K77R	NCI-H630	large intestine	COSMIC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation substituting flanking lysine	0.2778
p.E483D	CW-2	large intestine	COSMIC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.25
p.E496K	SNU-C5	large intestine	COSMIC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation rewiring degron network	0.1944
p.E19K	TGBC11TKB	stomach	COSMIC	SEETVPEA	DEG_COP1_1	2:9	Mutation rewiring degron network	0.0556
p.S488R	MFE-319	endometrium	COSMIC	VPLYTD	LIG_APCC_ABBA_1	486:491	Mutation altering degron motif	0.7427
p.P77L	CHL-1	skin	COSMIC	FREELEGLI	DEG_APCC_DBOX_1	63:71	Mutation substituting flanking lysine	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADD2

UniProt ID: P35612

Entrez ID: 119

Protein name: Beta-adducin (Erythrocyte adducin subunit beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADD2 in