DegronMD

Uniprot ID: P35612

Source protein: Beta-adducin

Source gene: ADD2

Class: LIG_APCC_ABBA_1

Location: 486:491

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9888

ASA_SCORE: 66.9167

COIL: 0.7965

CONS_SCORE: 0.4538

DSS_SCORE: 0.484

HELIX: 0.065

FCONS_SCORE: 1.0298

RIG_SCORE: 0.7872

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F485C	TCGA-AA-3510	COAD	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.3056
p.F485C	DO7783	COAD	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.3056
p.R478C	TCGA-AJ-A3EL	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	TCGA-BS-A0UF	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	TCGA-DK-A6AW	BLCA	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	DO48566	BLCA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	DO220902	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	DO222908	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	DO41542	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478C	DO41488	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.P476L	TCGA-AX-A1CE	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.0556
p.P476L	TCGA-FW-A3R5	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.0556
p.P476L	DO37406	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.0556
p.P476L	DO42280	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.0556
p.P492H	TCGA-D3-A3C6	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.3056
p.P492H	DO52512	EOPC	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.3056
p.P492H	DO37507	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.3056
p.E480K	TCGA-EE-A2GR	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	TCGA-ER-A19E	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	TCGA-W3-AA1R	SKCM	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	DO222710	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	DO222847	MELA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	DO37996	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	DO47542	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	DO51275	SKCM	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	SIDM00498	Colorectal Carcinoma	GDSC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	ACH-000970	Colon/Colorectal Cancer	CCLE	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.E480K	SNU-C5	large_intestine	COSMIC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.R478H	TCGA-FI-A2D5	UCEC	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.R478H	DO41331	UCEC	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1111
p.M498I	TCGA-JW-A5VL	CESC	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.1389
p.M498I	DO49976	CESC	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1389
p.P487S	TCGA-WS-AB45	COAD	TCGA	VPLYTD	LIG_APCC_ABBA_1	0.5641
p.P487S	DO51734	COAD	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.5641
p.E497D	DO218411	BTCA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1667
p.D491G	DO228280	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.7198
p.Q484K	DO228952	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.2778
p.L496M	DO228978	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.1944
p.N500K	DO229026	LICA	ICGC	VPLYTD	LIG_APCC_ABBA_1	0.0833
p.E483D	CW-2	large_intestine	COSMIC	VPLYTD	LIG_APCC_ABBA_1	0.25
p.E496K	SNU-C5	large_intestine	COSMIC	VPLYTD	LIG_APCC_ABBA_1	0.1944
p.S488R	MFE-319	endometrium	COSMIC	VPLYTD	LIG_APCC_ABBA_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPLYTD

Degron related mutations and impact score

Drug responses associated with ADD2 mutations

All proteins holding degron of VPLYTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35612	Beta-adducin	LIG_APCC_ABBA_1	486:491	VPLYTD	APC,CDC20,FZR1	0.9888	More...