DegronMD

Uniprot ID: P35612

Source protein: Beta-adducin

Source gene: ADD2

Class: DEG_COP1_1

Location: 2:9

E3 ligase: COP1

DEGRON score: 0.9638

ASA_SCORE: 108.3375

COIL: 0.9183

CONS_SCORE: 0.2313

DSS_SCORE: 0.9581

HELIX: 0.0493

FCONS_SCORE: 0.7087

RIG_SCORE: 0.6364

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13L	TCGA-12-0662	GBM	TCGA	SEETVPEA	DEG_COP1_1	0.2222
p.P13L	DO11358	GBM	ICGC	SEETVPEA	DEG_COP1_1	0.2222
p.E3K	TCGA-A6-5657	COAD	TCGA	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	TCGA-CG-5724	STAD	TCGA	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	TCGA-D9-A1JW	SKCM	TCGA	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	TCGA-OR-A5JS	ACC	TCGA	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	DO10459	COAD	ICGC	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	DO37786	SKCM	ICGC	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	DO38847	STAD	ICGC	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	SIDM00251	Gastric Carcinoma	GDSC	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	ACH-000949	Gastric Cancer	CCLE	SEETVPEA	DEG_COP1_1	0.7022
p.E3K	TGBC11TKB	stomach	COSMIC	SEETVPEA	DEG_COP1_1	0.7022
p.T5M	TCGA-AA-A02O	COAD	TCGA	SEETVPEA	DEG_COP1_1	0.7423
p.T5M	DO9226	COAD	ICGC	SEETVPEA	DEG_COP1_1	0.7423
p.T5M	SIDM01554	Mesothelioma	GDSC	SEETVPEA	DEG_COP1_1	0.7423
p.T5M	ACH-000331	Lung Cancer	CCLE	SEETVPEA	DEG_COP1_1	0.7423
p.P15S	TCGA-BF-A3DM	SKCM	TCGA	SEETVPEA	DEG_COP1_1	0.1667
p.P15S	DO48667	SKCM	ICGC	SEETVPEA	DEG_COP1_1	0.1667
p.G17W	TCGA-D3-A2JC	SKCM	TCGA	SEETVPEA	DEG_COP1_1	0.1111
p.G17W	DO47578	SKCM	ICGC	SEETVPEA	DEG_COP1_1	0.1111
p.P19L	TCGA-FR-A726	SKCM	TCGA	SEETVPEA	DEG_COP1_1	0.0556
p.P19L	DO48665	SKCM	ICGC	SEETVPEA	DEG_COP1_1	0.0556
p.T5A	TCGA-O2-A52Q	LUSC	TCGA	SEETVPEA	DEG_COP1_1	0.7139
p.T5A	DO219219	LUSC	ICGC	SEETVPEA	DEG_COP1_1	0.7139
p.T5A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SEETVPEA	DEG_COP1_1	0.7139
p.T5A	ACH-002101	Lung Cancer	CCLE	SEETVPEA	DEG_COP1_1	0.7139
p.T5A	EMC-BAC-1	lung	COSMIC	SEETVPEA	DEG_COP1_1	0.7139
p.E3A	DO228913	LICA	ICGC	SEETVPEA	DEG_COP1_1	0.7701
p.A10D	DO50678	ORCA	ICGC	SEETVPEA	DEG_COP1_1	0.3056
p.G15R	DO31624	OV	ICGC	SEETVPEA	DEG_COP1_1	0.1667
p.G15R	M14	skin	COSMIC	SEETVPEA	DEG_COP1_1	0.1667
p.G15R	NCI-H2342	lung	COSMIC	SEETVPEA	DEG_COP1_1	0.1667
p.A9V	DO232224	PBCA	ICGC	SEETVPEA	DEG_COP1_1	0.5825
p.A9V	GAK	skin	COSMIC	SEETVPEA	DEG_COP1_1	0.5825
p.G15E	DO51298	SKCM	ICGC	SEETVPEA	DEG_COP1_1	0.1667
p.R3C	DO42713	UCEC	ICGC	SEETVPEA	DEG_COP1_1	0.8301
p.E19K	TGBC11TKB	stomach	COSMIC	SEETVPEA	DEG_COP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SEETVPEA

Degron related mutations and impact score

Drug responses associated with ADD2 mutations

All proteins holding degron of SEETVPEA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35612	Beta-adducin	DEG_COP1_1	2:9	SEETVPEA	COP1	0.9638	More...