DegronMD

Uniprot ID: Q9BQG0

Source protein: Myb-binding protein 1A

Source gene: MYBBP1A

Class: DEG_APCC_DBOX_1

Location: 756:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7299

ASA_SCORE: 66.7778

COIL: 0.081

CONS_SCORE: 0.4812

DSS_SCORE: 0.6212

HELIX: 0.9163

FCONS_SCORE: 1.1174

RIG_SCORE: 0.7957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V763A	TCGA-AN-A0FZ	BRCA	TCGA	FREQLMTVL	DEG_APCC_DBOX_1	0.6936
p.V763A	DO1996	BRCA	ICGC	FREQLMTVL	DEG_APCC_DBOX_1	0.6936
p.R757Q	DO230347	COCA	ICGC	FREQLMTVL	DEG_APCC_DBOX_1	0.7329
p.M761L	SIDM01062	Breast Carcinoma	GDSC	FREQLMTVL	DEG_APCC_DBOX_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQG0	Myb-binding protein 1A	DEG_APCC_DBOX_1	756:764	FREQLMTVL	APC,CDC20,FZR1	0.7299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons