DegronMD - Q9BQG0(MYBBP1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V763A	TCGA-AN-A0FZ	BRCA	TCGA	FREQLMTVL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.6936
p.V763A	DO1996	BRCA	ICGC	FREQLMTVL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.6936
p.P1258L	TCGA-B5-A11Y	UCEC	TCGA	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.0556
p.P1258L	DO40889	UCEC	ICGC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.0556
p.A1246T	TCGA-BR-4370	STAD	TCGA	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation altering degron motif	0.6028
p.A1246T	DO38499	STAD	ICGC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation altering degron motif	0.6028
p.K1257R	DO230311	COCA	ICGC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation substituting flanking lysine	0.1944
p.K1257R	SIDM00333	Endometrial Carcinoma	GDSC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation substituting flanking lysine	0.1944
p.K1257R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation substituting flanking lysine	0.1944
p.K1257R	MFE-319	endometrium	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation substituting flanking lysine	0.1944
p.P1245S	DO230320	COCA	ICGC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation altering degron motif	0.6752
p.R757Q	DO230347	COCA	ICGC	FREQLMTVL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.7329
p.A1237T	DO227870	COCA	ICGC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.1944
p.M761L	SIDM01062	Breast Carcinoma	GDSC	FREQLMTVL	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.5999
p.T1239A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation blocking phosphorylation signal	0.6944
p.T1239A	ACH-002059	Leukemia	CCLE	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation blocking phosphorylation signal	0.6944
p.T1239A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation blocking phosphorylation signal	0.6944
p.A1234T	SIDM00282	Colorectal Carcinoma	GDSC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.1111
p.A1234T	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.1111
p.A1234T	CW-2	large intestine	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.1111
p.P1233S	SIDM01088	Endometrial Carcinoma	GDSC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.0833
p.P1233S	ACH-000965	Endometrial/Uterine Cancer	CCLE	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.0833
p.P1233S	RL95-2	endometrium	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	1242:1248	Mutation rewiring degron network	0.0833

Kaplan plot for MYBBP1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBBP1A

UniProt ID: Q9BQG0

Entrez ID: 10514

Protein name: Myb-binding protein 1A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYBBP1A in