DegronMD

Uniprot ID: Q9BQG0

Source protein: Myb-binding protein 1A

Source gene: MYBBP1A

Class: DEG_SCF_FBW7_1

Location: 1242:1248

E3 ligase: FBXW7

DEGRON score: 0.9417

ASA_SCORE: 94.7429

COIL: 0.9553

CONS_SCORE: 0.2718

DSS_SCORE: 0.8735

HELIX: 0.0296

FCONS_SCORE: 0.9038

RIG_SCORE: 0.5467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1258L	TCGA-B5-A11Y	UCEC	TCGA	PSTPAKS	DEG_SCF_FBW7_1	0.0556
p.P1258L	DO40889	UCEC	ICGC	PSTPAKS	DEG_SCF_FBW7_1	0.0556
p.A1246T	TCGA-BR-4370	STAD	TCGA	PSTPAKS	DEG_SCF_FBW7_1	0.6028
p.A1246T	DO38499	STAD	ICGC	PSTPAKS	DEG_SCF_FBW7_1	0.6028
p.K1257R	DO230311	COCA	ICGC	PSTPAKS	DEG_SCF_FBW7_1	0.1944
p.K1257R	SIDM00333	Endometrial Carcinoma	GDSC	PSTPAKS	DEG_SCF_FBW7_1	0.1944
p.K1257R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSTPAKS	DEG_SCF_FBW7_1	0.1944
p.K1257R	MFE-319	endometrium	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	0.1944
p.P1245S	DO230320	COCA	ICGC	PSTPAKS	DEG_SCF_FBW7_1	0.6752
p.A1237T	DO227870	COCA	ICGC	PSTPAKS	DEG_SCF_FBW7_1	0.1944
p.T1239A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PSTPAKS	DEG_SCF_FBW7_1	0.6944
p.T1239A	ACH-002059	Leukemia	CCLE	PSTPAKS	DEG_SCF_FBW7_1	0.6944
p.T1239A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	0.6944
p.A1234T	SIDM00282	Colorectal Carcinoma	GDSC	PSTPAKS	DEG_SCF_FBW7_1	0.1111
p.A1234T	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPAKS	DEG_SCF_FBW7_1	0.1111
p.A1234T	CW-2	large_intestine	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	0.1111
p.P1233S	SIDM01088	Endometrial Carcinoma	GDSC	PSTPAKS	DEG_SCF_FBW7_1	0.0833
p.P1233S	ACH-000965	Endometrial/Uterine Cancer	CCLE	PSTPAKS	DEG_SCF_FBW7_1	0.0833
p.P1233S	RL95-2	endometrium	COSMIC	PSTPAKS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQG0	Myb-binding protein 1A	DEG_SCF_FBW7_1	1242:1248	PSTPAKS	FBXW7	0.9417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons