DegronMD

Uniprot ID: Q9NRG9

Source protein: Aladin

Source gene: AAAS

Class: DEG_MDM2_SWIB_1

Location: 38:45

E3 ligase: MDM2

DEGRON score: 0.8615

ASA_SCORE: 59.475

COIL: 0.6519

CONS_SCORE: 0.4426

DSS_SCORE: 0.4085

HELIX: 0.216

FCONS_SCORE: 1.0643

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G40C	TCGA-99-8028	LUAD	TCGA	FRGQWINL	DEG_MDM2_SWIB_1	0.6489
p.G40C	DO23561	LUAD	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.6489
p.P35L	TCGA-CV-A468	HNSC	TCGA	FRGQWINL	DEG_MDM2_SWIB_1	0.25
p.P35L	DO52070	HNSC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.25
p.W42L	TCGA-ER-A2NH	SKCM	TCGA	FRGQWINL	DEG_MDM2_SWIB_1	0.7015
p.P35T	DO228976	LICA	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.25
p.L47I	DO228985	LICA	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.2778
p.C28F	DO50966	LICA	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.0556
p.R31L	DO27302	LUSC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.1389
p.R31H	DO41871	UCEC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.1389
p.R31C	DO43899	UCEC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	0.1389
p.P54S	SIDM01446	Glioblastoma	GDSC	FRGQWINL	DEG_MDM2_SWIB_1	0.0833
p.P54S	ACH-000543	Brain Cancer	CCLE	FRGQWINL	DEG_MDM2_SWIB_1	0.0833
p.P36S	ACH-002672	Pancreatic Cancer	CCLE	FRGQWINL	DEG_MDM2_SWIB_1	0.2778
p.V32D	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	FRGQWINL	DEG_MDM2_SWIB_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRG9	Aladin	DEG_MDM2_SWIB_1	38:45	FRGQWINL	MDM2	0.8615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons