DegronMD - Q9NRG9(AAAS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G40C	TCGA-99-8028	LUAD	TCGA	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation altering degron motif	0.6489
p.G40C	DO23561	LUAD	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation altering degron motif	0.6489
p.D514G	TCGA-A5-A0G2	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation rewiring degron network	0.3056
p.P516L	TCGA-AA-A022	COAD	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation altering degron motif	0.6471
p.P35L	TCGA-CV-A468	HNSC	TCGA	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.25
p.P35L	DO52070	HNSC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.25
p.D529N	TCGA-DF-A2KN	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation rewiring degron network	0.0833
p.P530H	TCGA-EE-A2M8	SKCM	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation rewiring degron network	0.0556
p.P523Q	TCGA-EE-A3J5	SKCM	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation rewiring degron network	0.25
p.S522Y	TCGA-EO-A22R	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation blocking phosphorylation signal	0.7222
p.W42L	TCGA-ER-A2NH	SKCM	TCGA	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation altering degron motif	0.7015
p.D529G	TCGA-EY-A1GO	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation rewiring degron network	0.0833
p.L517I	TCGA-HU-A4H3	STAD	TCGA	LPLFTE	LIG_APCC_ABBA_1	515:520	Mutation altering degron motif	0.6063
p.P35T	DO228976	LICA	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.25
p.L47I	DO228985	LICA	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.2778
p.C28F	DO50966	LICA	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.0556
p.R31L	DO27302	LUSC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.1389
p.R31H	DO41871	UCEC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.1389
p.R31C	DO43899	UCEC	ICGC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.1389
p.P54S	SIDM01446	Glioblastoma	GDSC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.0833
p.P54S	ACH-000543	Brain Cancer	CCLE	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.0833
p.P36S	ACH-002672	Pancreatic Cancer	CCLE	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.2778
p.V32D	RS4-11	haematopoietic and lymphoid tissue	COSMIC	FRGQWINL	DEG_MDM2_SWIB_1	38:45	Mutation rewiring degron network	0.1667

Kaplan plot for AAAS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AAAS

UniProt ID: Q9NRG9

Entrez ID: 8086

Protein name: Aladin (Adracalin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AAAS in