DegronMD

Uniprot ID: Q9NRG9

Source protein: Aladin

Source gene: AAAS

Class: LIG_APCC_ABBA_1

Location: 515:520

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9926

ASA_SCORE: 70.2

COIL: 0.6758

CONS_SCORE: 0.4108

DSS_SCORE: 0.6312

HELIX: 0.0968

FCONS_SCORE: 0.9862

RIG_SCORE: 0.6998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D514G	TCGA-A5-A0G2	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.3056
p.P516L	TCGA-AA-A022	COAD	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.6471
p.D529N	TCGA-DF-A2KN	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.0833
p.P530H	TCGA-EE-A2M8	SKCM	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.0556
p.P523Q	TCGA-EE-A3J5	SKCM	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.25
p.S522Y	TCGA-EO-A22R	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.7222
p.D529G	TCGA-EY-A1GO	UCEC	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.0833
p.L517I	TCGA-HU-A4H3	STAD	TCGA	LPLFTE	LIG_APCC_ABBA_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRG9	Aladin	LIG_APCC_ABBA_1	515:520	LPLFTE	APC,CDC20,FZR1	0.9926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons