DegronMD

Uniprot ID: Q9C0K0

Source protein: B-cell lymphoma/leukemia 11B

Source gene: BCL11B

Class: LIG_APCC_ABBA_1

Location: 246:251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9997

ASA_SCORE: 80.35

COIL: 0.8185

CONS_SCORE: 0.5439

DSS_SCORE: 0.3797

HELIX: 0.0463

FCONS_SCORE: 1.0601

RIG_SCORE: 0.789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I248M	TCGA-4Z-AA87	BLCA	TCGA	FRIYLE	LIG_APCC_ABBA_1	0.6507
p.I248M	ACH-000690	Lung Cancer	CCLE	FRIYLE	LIG_APCC_ABBA_1	0.6507
p.H244N	TCGA-97-7938	LUAD	TCGA	FRIYLE	LIG_APCC_ABBA_1	0.2778
p.H244N	DO24329	LUAD	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.2778
p.L237P	TCGA-FA-A4XK	DLBC	TCGA	FRIYLE	LIG_APCC_ABBA_1	0.0833
p.L237P	DO219886	DLBC	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.0833
p.R247S	TCGA-G3-A25T	LIHC	TCGA	FRIYLE	LIG_APCC_ABBA_1	0.6316
p.A240E	TCGA-KK-A8ID	PRAD	TCGA	FRIYLE	LIG_APCC_ABBA_1	0.1667
p.P243L	DO222651	BTCA	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.25
p.P243L	DO229010	COCA	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.25
p.P249T	DO233272	GACA	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.7031
p.F244L	DO231690	LINC	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.2778
p.R247C	DO33376	PACA	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.719
p.E236K	DO37425	SKCM	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.0556
p.E236K	DO51276	SKCM	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.0556
p.R238C	DO48547	STAD	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.1111
p.F237L	DO38376	STAD	ICGC	FRIYLE	LIG_APCC_ABBA_1	0.0833
p.F237L	HEC-1	endometrium	COSMIC	FRIYLE	LIG_APCC_ABBA_1	0.0833
p.R247H	SIDM00100	Mesothelioma	GDSC	FRIYLE	LIG_APCC_ABBA_1	0.7133
p.R247H	ACH-001369	Ovarian Cancer	CCLE	FRIYLE	LIG_APCC_ABBA_1	0.7133
p.R247H	ACH-002127	Lung Cancer	CCLE	FRIYLE	LIG_APCC_ABBA_1	0.7133
p.R247H	H2595	pleura	COSMIC	FRIYLE	LIG_APCC_ABBA_1	0.7133
p.V250M	RL95-2	endometrium	COSMIC	FRIYLE	LIG_APCC_ABBA_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0K0	B-cell lymphoma/leukemia 11B	LIG_APCC_ABBA_1	246:251	FRIYLE	APC,CDC20,FZR1	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons