DegronMD - Q9C0K0(BCL11B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E111K	TCGA-2W-A8YY	CESC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.E111K	DO223732	CESC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.E111K	DO220841	MELA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.E111K	SIDM01083	Oral Cavity Carcinoma	GDSC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.E111K	ACH-000254	Head and Neck Cancer	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.E111K	SCC-15	upper aerodigestive tract	COSMIC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.I248M	TCGA-4Z-AA87	BLCA	TCGA	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.6507
p.I248M	ACH-000690	Lung Cancer	CCLE	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.6507
p.P112L	TCGA-50-5055	LUAD	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.P112L	DO25454	LUAD	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.P112L	DO229446	SKCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.P271Q	TCGA-86-8358	LUAD	TCGA	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1389
p.H244N	TCGA-97-7938	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.H244N	TCGA-97-7938	LUAD	TCGA	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.2778
p.H244N	DO24329	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.H244N	DO24329	LUAD	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.2778
p.T260M	TCGA-AJ-A3BG	UCEC	TCGA	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.8534
p.T260M	TCGA-CM-6162	COAD	TCGA	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.8534
p.E114D	TCGA-AP-A1DV	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.E114D	DO43186	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.E105K	TCGA-B5-A11E	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.591
p.E105K	TCGA-CG-5723	STAD	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.591
p.E105K	DO38376	STAD	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.591
p.E105K	DO41644	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.591
p.S257N	TCGA-B5-A1MX	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.818
p.G116E	TCGA-BF-A1Q0	SKCM	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.G116E	DO47374	SKCM	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.D94E	TCGA-BF-A1Q0	SKCM	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1111
p.D94E	DO47374	SKCM	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1111
p.V113M	TCGA-EB-A3Y6	SKCM	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.V113M	DO38081	SKCM	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.R103H	TCGA-EO-A22R	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.8244
p.R103H	DO42713	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.8244
p.S104C	TCGA-EO-A3L0	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.643
p.S104C	DO219775	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.643
p.L237P	TCGA-FA-A4XK	DLBC	TCGA	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.0833
p.L237P	DO219886	DLBC	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.0833
p.R247S	TCGA-G3-A25T	LIHC	TCGA	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.6316
p.A240E	TCGA-KK-A8ID	PRAD	TCGA	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.1667
p.G116R	DO1131	BRCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.G116R	DO218900	SKCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.P243L	DO222651	BTCA	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.25
p.P243L	DO229010	COCA	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.25
p.R115H	DO227549	COCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1944
p.E262K	DO233261	GACA	ICGC	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7022
p.P249T	DO233272	GACA	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.7031
p.R99H	DO233634	GACA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.A255S	DO19380	KIRC	ICGC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.6477
p.P256S	DO50163	LGG	ICGC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.6752
p.P117T	DO229024	LICA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1389
p.F244L	DO231690	LINC	ICGC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.F244L	DO231690	LINC	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.2778
p.R247C	DO33376	PACA	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.719
p.G265W	DO36360	PRAD	ICGC	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.3056
p.G265W	DO36360	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.E236K	DO37425	SKCM	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.0556
p.E236K	DO51276	SKCM	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.0556
p.E263K	DO50301	SKCM	ICGC	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7022
p.R238C	DO48547	STAD	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.1111
p.F237L	DO38376	STAD	ICGC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.0833
p.F237L	HEC-1	endometrium	COSMIC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation rewiring degron network	0.0833
p.P98L	SIDM00798	Rhabdomyosarcoma	GDSC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.L93M	SIDM01206	Neuroblastoma	GDSC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.L93M	ACH-000310	Neuroblastoma	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.L93M	ACH-002248	Neuroblastoma	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.L93M	IMR-5	autonomic ganglia	COSMIC	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.P266A	SIDM00032	Bladder Carcinoma	GDSC	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2778
p.P266A	SIDM00032	Bladder Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.P266A	ACH-000839	Bladder Cancer	CCLE	LTPRLT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2778
p.P266A	ACH-000839	Bladder Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R247H	SIDM00100	Mesothelioma	GDSC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.7133
p.R247H	ACH-001369	Ovarian Cancer	CCLE	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.7133
p.R247H	ACH-002127	Lung Cancer	CCLE	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.7133
p.R247H	H2595	pleura	COSMIC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.7133
p.S97I	ACH-000072	Leukemia	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	102:110	Mutation blocking phosphorylation signal	0.6389
p.P254S	ACH-000509	Lymphoma	CCLE	PASSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.6752
p.V250M	RL95-2	endometrium	COSMIC	FRIYLE	LIG_APCC_ABBA_1	246:251	Mutation altering degron motif	0.7208
p.T256M	SNU-407	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.7423

Kaplan plot for BCL11B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL11B

UniProt ID: Q9C0K0

Entrez ID: 64919

Protein name: B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL11B in